Steroid hormones, ageing and bone.
Steroid hormones, ageing and bone.
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类固醇激素、衰老和骨骼。
DOI：
10.1016/s0300-595x(81)80041-2
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
B. Nordin
中科院分区：
文献类型：
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作者：
R. Crilly;R. Francis;B. Nordin
类固醇激素包括直接或间接来源于肾上腺和性腺的广泛的调节化合物。它们中的一些的血浆水平由涉及来自垂体的营养激素的负反馈系统维持，而另一些则不太精确地控制。这些化合物中的某些直接由相关腺体分泌，而另一些则通过外周组织或肝脏中的转化产生。结果是，类固醇激素的年龄相关变化是复杂的，并受到相当大的个体差异。其中一些激素（如皮质醇和醛固酮）对生命是必不可少的;另一些（如雌激素和睾酮）对生殖是必不可少的;而另一些（如较弱的雄激素）在维持正常健康方面的作用不太明确。这些激素对特定靶组织的作用已相当清楚，但它们对其他组织（如肌肉和骨骼）的作用虽然已得到充分认识，但尚未完全阐明。特别是，年龄依赖性骨丢失和激素变化之间的关系是非常有争议的，我们将试图在本章中回顾这一领域。就我们使用自己的数据而言，我们将依赖于在别处已充分描述过的方法（Nordin，1976）。
The steroid hormones comprise a wide range of regulatory compounds derived directly or indirectly from the adrenals and the gonads. The plasma levels of some of them are maintained by negative feedback systems involving trophic hormones from the pituitary, whereas others are less precisely controlled. Certain of these compounds are directly secreted by the relevant glands, whereas others are produced by conversion in the peripheral tissues or the liver. The result is that the age-related changes in steroid hormones are complex and subject to considerable individual variation. Some of these hormones (eg cortisol and aldosterone) are essential to life; others (such as oestrogens and testosterone) are essential to reproduction; and others again (such as the weaker androgens) have a less well-defined role in the maintenance of normal health. The action of these hormones on their specific target tissues are reasonably well understood, but their effects on other tissues, such as muscle and bone, though well recognized, have not been fully elucidated. In particular, the relationship between age-dependent bone loss and hormonal changes is very controversial, and we shall attempt to review this area in this chapter. In so far as we make use of our own data, we will be relying on methodology which has been fully described elsewhere (Nordin, 1976).