A Biomimetic Zinc Alloy Scaffold Coated with Brushite for Enhanced Cranial Bone Regeneration.
A Biomimetic Zinc Alloy Scaffold Coated with Brushite for Enhanced Cranial Bone Regeneration.
复制标题
DOI：
10.1021/acsbiomaterials.9b01895
复制
发表时间：
2020-07
影响因子：
5.8
通讯作者：
Yu Zhuang;Qingcheng Liu;Gaozhi Jia;Hongliang Li;G. Yuan;Hongbo Yu
中科院分区：
文献类型：
--
作者：
Yu Zhuang;Qingcheng Liu;Gaozhi Jia;Hongliang Li;G. Yuan;Hongbo Yu
骨组织工程被认为是一种很有前途的骨再生和缺损重建途径，其中支架在骨组织工程中起着重要的作用。锌合金作为一种生物可降解的金属材料，具有金属和生物可降解特性的优点，具有其独特的特性，特别是理想的降解率和可接受的生物相容性，值得进一步研究其在医学上的应用。本研究尝试采用新型可生物降解多孔锌合金Ca-P涂层支架修复颅骨缺损，并对其生物相容性、成骨诱导性和骨导电性进行了体外和体内试验。结果表明，镀层锌合金具有良好的生物相容性，无细胞毒性。在体外可促进兔骨髓间充质干细胞成骨分化和钙沉积，在体内可促进支架周围新骨的形成。生物可降解多孔锌合金钙磷涂层支架在颅骨骨缺损修复中具有广阔的应用前景。
Bone tissue engineering is considered as a promising pathway for bone regeneration and defect reconstruction, in which scaffolds play an important role. Zn alloy, which is a biodegradable metal material that has advantages of metallic and biodegradable characteristics, has its special features, especially the ideal degradation rate and acceptable biocompatibility, which make it worthy to be further investigated for medical applications. In this study, new biodegradable porous Zn alloy scaffolds with Ca-P coating were attempted to repair cranial bone defect, and in vitro and in vivo assays were conducted to evaluate its biocompatibility, osteo-inductivity, and osteo-conductivity. The results indicated that coated Zn alloy possessed good biocompatibility, with no cytotoxicity. It could also promote osteogenic differentiation and calcium deposition of rabbit BMSCs in vitro, and new bone formation around the scaffold in vivo. The biodegradable porous Zn alloy scaffold with Ca-P coating is considered to be promising in cranial bone defect repair.