Modular Design of Immunological Synapses and Kinapses
Modular Design of Immunological Synapses and Kinapses
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DOI：
10.1101/cshperspect.a002873
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发表时间：
2009-07-01
影响因子：
7.2
通讯作者：
Dustin, Michael L.
中科院分区：
文献类型：
--
作者：
Dustin, Michael L.
免疫突触的概念可以追溯到20世纪80年代初，当时发现了t细胞抗原受体介导的Ca2+信号、粘附和定向分泌之间的关系。然而，直到1998年开始发表的图像揭示了T细胞和模型抗原提呈细胞或支持的平面双层之间的界面中的特定分子模式，这一概念才获得关注。在两个模型系统中都观察到显性模式，即围绕抗原受体中心簇的粘附分子环。过去10年对这种模式起源的分析为淋巴细胞生物学中的一个难题提供了一个解决方案——当一个高度运动性的细胞遇到另一个细胞表面上的几个抗原配体传递的信号时，它是如何突然停止的，而不会使运动细胞的感觉机制失效。T淋巴细胞根据基于肌动蛋白-肌球蛋白的运动性的模块化设计积极地组装免疫突触模式。
The concept of an immunological synapse goes back to the early 1980s with the discovery of the relationship between T-cell antigen receptor mediated Ca2+ signaling, adhesion, and directed secretion. However, this concept did not gain traction until images were published starting in 1998 that revealed a specific molecular pattern in the interface between T cells and model antigen-presenting cells or supported planar bilayers. The dominant pattern, a ring of adhesion molecules surrounding a central cluster of antigen receptors, was observed in both model systems. Analysis of the origins of this pattern over the past 10 years has presented a solution for a difficult problem in lymphocyte biology-how a highly motile cell can suddenly stop when it encounters a signal delivered by just a few antigenic ligands on the surface of another cell without disabling the sensory machinery of the motile cell. The T lymphocyte actively assembles the immunological synapse pattern following a modular design with roots in actin-myosin-based motility.