Gradient sensing during chemotaxis
Gradient sensing during chemotaxis
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DOI：
10.1016/j.ceb.2013.06.007
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发表时间：
2013-10-01
影响因子：
7.5
通讯作者：
Jin, Tian
中科院分区：
文献类型：
--
作者：
Jin, Tian
真核细胞具有感知化学引诱剂梯度并向引诱剂来源迁移的能力。化学梯度引导的细胞运动被称为趋化性。趋化剂是由g蛋白偶联受体（gpcr）的成员检测到的，该受体与异源三聚体g蛋白相连。GPCR/ g蛋白传感机制能够将外部化学引诱剂场转化为细胞间信号，从而指导驱动细胞运动的肌动蛋白细胞骨架的重组。在这里，我回顾了我们目前对体内化学引诱剂梯度的形成、gpcr介导的梯度传感以及指导肌动蛋白细胞骨架功能的复杂信号网络的理解。
Eukaryotic cells have the ability to sense chemoattractant gradients and to migrate toward the sources of attractants. The chemical gradient-guided cell movement is referred to as chemotaxis. Chemoattractants are detected by members of G-protein-coupled receptors (GPCRs) that link to heterotrimeric G-proteins. The GPCR/G-protein sensing machinery is able to translate external chemoattractants fields into intercellular cues, which direct reorganization of the actin cytoskeleton that drives cell movement. Here, I review our current understanding of the formation of chemoattractant gradients in vivo, the GPCR-mediated gradient sensing, and the sophisticated signaling network that guides the function of the actin cytoskeleton.