Pestalazines and Pestalamides, Bioactive Metabolites from the Plant Pathogenic Fungus Pestalotiopsis theae
Pestalazines and Pestalamides, Bioactive Metabolites from the Plant Pathogenic Fungus Pestalotiopsis theae
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多司他嗪和多司他酰胺是植物病原真菌多盘拟盘菌的生物活性代谢物
DOI：
10.1021/np800357g
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发表时间：
2008-11-01
影响因子：
5.1
通讯作者：
Che, Yongsheng
中科院分区：
文献类型：
--
作者：
Ding, Gang;Jiang, Lihua;Che, Yongsheng
从植物病原真菌茶拟盘多毛孢（Pestalotiopsis theae）的培养物中分离得到两个新的二酮哌嗪异二聚体-这些化合物的结构主要通过核磁共振波谱进行了鉴定。I和2的绝对构型是用马氏法测定的，并与模型化合物的CD谱进行了比较。化合物1、3和6对C8166细胞中的HIV-1复制具有抑制作用。化合物3对烟曲霉也表现出较强的抗真菌活性。
Pestalazines A (1) and B (2), two new diketopiperazine heterodimers, and pestalamides A-C (3-5), three new amides, have been isolated from cultures of the plant pathogenic fungus Pestalotiopsis theae. The structures of these compounds were elucidated mainly by NMR spectroscopy. The absolute configurations of I and 2 were determined using Marfey's method on their acid hydrolysates and by comparison of their CD spectra with that of a model compound. Compounds 1, 3, and 6 displayed inhibitory effects on HIV-1 replication in C8166 cells. Compound 3 also showed potent antifungal activity against Aspergillus fumigatus.