Gene set enrichment analysis for genome-wide DNA methylation data.
Gene set enrichment analysis for genome-wide DNA methylation data.
复制标题
DOI：
10.1186/s13059-021-02388-x
复制
发表时间：
2021-06-08
期刊：
影响因子：
12.3
通讯作者：
Phipson B
中科院分区：
文献类型：
--
作者：
Maksimovic J;Oshlack A;Phipson B
DNA甲基化是最常研究的表观遗传标记之一，因为它在疾病和发育中起作用。Illumina甲基化阵列已被广泛用于测量人类基因组中的甲基化。甲基化阵列分析主要集中在差异甲基化CpG和区域的预处理、标准化和鉴定。GOmeth和GOregion是在差异甲基化分析之后进行无偏基因集测试的新方法。基准分析表明GOmeth优于其他方法，GOregion是第一种用于差异甲基化区域的基因集测试的方法。这两种方法都可以在missMethyl Bioconductor R包中公开获得。在线版本包含补充材料，可通过10.1186/s13059-021-02388-x获得。
DNA methylation is one of the most commonly studied epigenetic marks, due to its role in disease and development. Illumina methylation arrays have been extensively used to measure methylation across the human genome. Methylation array analysis has primarily focused on preprocessing, normalization, and identification of differentially methylated CpGs and regions. GOmeth and GOregion are new methods for performing unbiased gene set testing following differential methylation analysis. Benchmarking analyses demonstrate GOmeth outperforms other approaches, and GOregion is the first method for gene set testing of differentially methylated regions. Both methods are publicly available in the missMethyl Bioconductor R package. The online version contains supplementary material available at 10.1186/s13059-021-02388-x.
登录
查看更多内容
影响因子：
48
作者：
Huber W;Carey VJ;Gentleman R;Anders S;Carlson M;Carvalho BS;Bravo HC;Davis S;Gatto L;Girke T;Gottardo R;Hahne F;Hansen KD;Irizarry RA;Lawrence M;Love MI;MacDonald J;Obenchain V;Oleś AK;Pagès H;Reyes A;Shannon P;Smyth GK;Tenenbaum D;Waldron L;Morgan M
通讯作者：
Morgan M
影响因子：
12.3
作者：
Gentleman RC;Carey VJ;Bates DM;Bolstad B;Dettling M;Dudoit S;Ellis B;Gautier L;Ge Y;Gentry J;Hornik K;Hothorn T;Huber W;Iacus S;Irizarry R;Leisch F;Li C;Maechler M;Rossini AJ;Sawitzki G;Smith C;Smyth G;Tierney L;Yang JY;Zhang J
通讯作者：
Zhang J
影响因子：
14.9
作者：
Liu R;Holik AZ;Su S;Jansz N;Chen K;Leong HS;Blewitt ME;Asselin-Labat ML;Smyth GK;Ritchie ME
通讯作者：
Ritchie ME
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.1
作者：
Irizarry, RA;Hobbs, B;Speed, TP
通讯作者：
Speed, TP