BMI, waist circumference, and clustering of cardiovascular risk factors in Japanese adults
BMI, waist circumference, and clustering of cardiovascular risk factors in Japanese adults
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DOI：
10.1007/s12199-010-0169-7
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发表时间：
2011-03-01
影响因子：
4.7
通讯作者：
Yanagisawa, Hiroyuki
中科院分区：
文献类型：
--
作者：
Suka, Machi;Miwa, Yuichi;Yanagisawa, Hiroyuki
目的探讨腰围（WC）与心血管危险因素聚类的关系是否因肥胖（BMI）状况而异。方法利用日本卫生服务协会2008年健康体检资料，选取57,141名年龄在20-65岁之间、无冠心病或中风的成年人，在空腹状态下采集血样。参与者被分为体重过轻（BMI < 18.5）、体重正常（BMI 18.5-24.9）和超重（BMI >= 25.0）。采用多元logistic回归分析计算心血管危险因素聚类的校正优势比（OR）。进行受试者工作特征分析，以评估WC区分有或没有心血管危险因素聚类的受试者的能力。结果16.0%的男性和3.4%的女性存在心血管危险因素聚类。体重过轻组、正常组和超重组的腰围每增加5厘米，调整后的OR[95%可信区间（CI）]男性分别为1.57（1.12-2.20）、1.55（1.49-1.62）和1.34(1.30-1.38)，女性分别为1.50（0.84-2.69）、1.53（1.40-1.68）和1.32（1.23-1.41）。男性体重过轻、正常体重和超重组的曲线下面积（95% CI）分别为0.68（0.59-0.77）、0.70（0.69-0.71）和0.62(0.61-0.63)，女性分别为0.70（0.53-0.86）、0.75（0.73-0.78）和0.64（0.61-0.68）。结论高腰围与独立于BMI的心血管危险因素聚类风险增加有关。除了相关性的程度外，WC区分有或没有心血管危险因素聚类的受试者的能力也因肥胖（BMI）状况而异。
Objective To examine whether the association between waist circumference (WC) and clustering of cardiovascular risk factors varies with obesity (BMI) status.Methods Using the 2008 health examination data of a Japanese health service association, eligible 57,141 adults aged 20-65 years without coronary heart disease or stroke, whose blood sample had been taken in the fasting state, were enrolled in the study. The participants were classified as being underweight (BMI < 18.5), normal weight (BMI 18.5-24.9), and overweight (BMI >= 25.0). Multiple logistic regression analysis was performed to calculate adjusted odds ratios (OR) for clustering of cardiovascular risk factors. Receiver operating characteristic analysis was performed to assess the ability of WC to discriminate subjects with and without a clustering of cardiovascular risk factors.Results Clustering of cardiovascular risk factors was found in 16.0% of men and 3.4% of women. The adjusted OR [95% confidence intervals (CI)] per 5-cm increase in WC of the underweight, normal weight, and overweight groups was 1.57 (1.12-2.20), 1.55 (1.49-1.62), and 1.34 (1.30-1.38), respectively, for men and 1.50 (0.84-2.69), 1.53 (1.40-1.68), and 1.32 (1.23-1.41), respectively, for women. The area under curve (95% CI) of the underweight, normal weight, and overweight groups was 0.68 (0.59-0.77), 0.70 (0.69-0.71), and 0.62 (0.61-0.63), respectively, for men and 0.70 (0.53-0.86), 0.75 (0.73-0.78), and 0.64 (0.61-0.68), respectively, for women.Conclusion High WC was associated with increased risk of clustering of cardiovascular risk factors independent of BMI. As well as the magnitude of the association, the ability of WC to discriminate subjects with and without a clustering of cardiovascular risk factors varied with obesity (BMI) status.