Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo
Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo
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DOI：
10.1161/01.res.83.5.568
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发表时间：
1998-09-07
影响因子：
20.1
通讯作者：
Winslow, RM
中科院分区：
文献类型：
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作者：
Motterlini, R;Gonzales, A;Winslow, RM
血红素加氧酶以诱导型（HO-1）和组成型（HO-2）异构体存在，在哺乳动物组织中催化血红素降解为胆绿素和CO。在本研究中，我们研究了血红素加氧酶/CO通路对体内急性高血压反应的调节作用，所述急性高血压反应由（1）α α Hb（已知为NO的化学修饰的血红蛋白）和（2）N-G-硝基-L-精氨酸甲酯（L-NAME）（竞争性NOS抑制剂）诱导。实验在清醒的大鼠中进行，其中在用血管收缩剂治疗前1或5天，对股动脉和静脉进行手术导管插入。静脉滴注aa Hb（18%溶液）或L-NAME（30 mmol/kg）均使平均动脉压显著升高（P
The enzyme heme oxygenase, which exists in inducible (HO-1) and constitutive (HO-2) isoforms, catalyzes the degradation of heme to biliverdin and CO in mammalian tissues. CO has been implicated in the control of vascular tone in a manner similar to that for NO In the present study, we investigated the contribution of the heme oxygenase/CO pathway to the modulation of acute hypertensive responses in vivo induced by (1) alpha alpha Hb, a chemically modified hemoglobin known to scavenge NO, and (2) N-G-nitro-L-arginine methyl ester (L-NAME), a competitive NOS inhibitor. Experiments were carried out in conscious rats in which femoral arteries ansi veins were surgically catheterized 1 or 5 days before treatment with the vasoconstrictor agents. Intravenous infusion of aa Hb 18% solution) or L-NAME (30 mmol/kg) produced an acute and significant increase in mean arterial pressure (P