The effects of antioxidants in the senescent auditory cortex.

The effects of antioxidants in the senescent auditory cortex.
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抗氧化剂对衰老听觉皮层的影响。

DOI:
10.1016/j.neurobiolaging.2005.05.003
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发表时间:
2006
影响因子:
4.2
通讯作者:
Mendelson,JR
Mendelson,JR
中科院分区:
医学2区
文献类型:
--
作者:
deRivera,C;Shukitt-Hale,B;Joseph,JA;Mendelson,JR

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We investigated whether a 2-month dietary supplementation of antioxidants, in the form of blueberry phytochemicals, could reverse or retard the age-related decline in temporal processing speed observed in the aged rat. To this end, extracellular single unit responses to frequency modulated (FM) sweeps were recorded in the primary auditory cortex (AI) of aged rats that had been placed on either a blueberry-supplemented or control diet 2 months prior to the physiological recordings. Results showed that most cells recorded from the blueberry-fed rats responded most vigorously to fast FM sweeps, similar to that observed in young rats. In contrast, the majority of cells recorded from the control rats showed a preference for slow FM sweep rates. These results suggest that age-related changes in temporal processing speed in A1 may be reversed by dietary supplementation of blueberry phytochemicals.
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DOI: --
发表时间: 1987
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DOI: --
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期刊: The Journal of biological chemistry
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DOI: 10.1016/0014-5793(86)80437-9
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期刊: FEBS LETTERS
影响因子: 3.5
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DOI: 10.1016/0022-1759(86)90417-5
发表时间: 1986
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影响因子: 11.1
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通讯作者: TACK, BF