INTERLEUKIN-1 RECEPTOR ANTAGONIST GENE POLYMORPHISM AS A DISEASE SEVERITY FACTOR IN SYSTEMIC LUPUS-ERYTHEMATOSUS
INTERLEUKIN-1 RECEPTOR ANTAGONIST GENE POLYMORPHISM AS A DISEASE SEVERITY FACTOR IN SYSTEMIC LUPUS-ERYTHEMATOSUS
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DOI：
10.1002/art.1780370917
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发表时间：
1994-09-01
影响因子：
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通讯作者：
DUFF, GW
中科院分区：
文献类型：
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作者：
BLAKEMORE, AIF;TARLOW, JK;DUFF, GW
Objective.我们以前描述了白细胞介素-1受体拮抗剂基因（IL 1 RN）的等位基因和几种炎症性疾病之间的关联。在这项研究中，我们测试了IL 1 RN基因作为一个可能的标志物在系统性红斑狼疮（SLE）患者。采用聚合酶链反应对81例SLE患者和261例种族匹配的对照者进行基因分型。我们发现SLE组中IL 1 RN *2的频率和携带率均增加。这种关联随着广泛的疾病而加强，特别是与光敏性和盘状皮肤病变的存在。我们描述了IL 1 RN *2和SLE之间的新关联。等位基因的携带似乎影响SLE的严重程度，而不是易感性。我们推测，这种多态性与疾病严重程度的关联是常见炎症和自身免疫性疾病的普遍特征。
Objective. We have previously described associations between an allele of the interleukin-1 receptor antagonist gene (IL1RN) and several inflammatory diseases. In this study we tested the IL1RN gene as a possible marker in patients with systemic lupus erythematosus (SLE).Methods. Eighty-one SLE patients and 261 ethnically matched control subjects were genotyped by polymerase chain reaction.Results. We found an increase in both frequency and carriage rate of IL1RN*2 in the SLE group. This association strengthened with extensive disease and particularly with the presence of photosensitivity and discoid skin lesions.Conclusion. We describe a novel association between IL1RN*2 and SLE. Carriage of the allele seems to influence severity rather than susceptibility to SLE. We postulate that the association of this polymorphism with disease severity is a widespread feature of common inflammatory and autoimmune diseases.