Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases.
Mitochondrial-Encoded Peptide MOTS-c, Diabetes, and Aging-Related Diseases.
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DOI：
10.4093/dmj.2022.0333
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发表时间：
2023-05
影响因子：
5.9
通讯作者：
Cho YM
中科院分区：
文献类型：
--
作者：
Kong BS;Lee C;Cho YM
线粒体是复杂的代谢细胞器，在糖尿病中具有多种病理生理学意义。目前公开的由线粒体12 S核糖体RNA C型（MOTS-c）、16 S rRNA和16 S rRNA的开放阅读框表达的线粒体编码的肽，（humanin和短humanin样肽1-6 [SHLP 1 -6]）或小的人线粒体丝氨酸tRNA开放阅读框（SHMOOSE）与年龄相关疾病中细胞代谢和胰岛素作用的调节有关，例如2型糖尿病。本文主要介绍MOTS-c与糖尿病（包括1型和2型）相关研究的最新进展。对MOTS-c在糖尿病中的新认识可能为糖尿病和其他年龄或衰老相关疾病的新疗法的开发提供见解。
Mitochondria are complex metabolic organelles with manifold pathophysiological implications in diabetes. Currently published mitochondrial-encoded peptides, which are expressed from the mitochondrial open reading frame of the 12S ribosomal RNA type-c (MOTS-c), 16S rRNA (humanin and short humanin like peptide 1-6 [SHLP1-6]), or small human mitochondrial open reading frame over serine tRNA (SHMOOSE) are associated with regulation of cellular metabolism and insulin action in age-related diseases, such as type 2 diabetes mellitus. This review focuses mainly on recent advances in MOTS-c research with regards to diabetes, including both type 1 and type 2. The emerging understanding of MOTS-c in diabetes may provide insight into the development of new therapies for diabetes and other age or senescence-related diseases.