Early detection of lung disease in children with cystic fibrosis using lung function
Early detection of lung disease in children with cystic fibrosis using lung function
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DOI：
10.1016/j.prrv.2008.05.002
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发表时间：
2008-09-01
影响因子：
5.8
通讯作者：
Hall, Graham
中科院分区：
文献类型：
--
作者：
Ranganathan, Sarath;Linnane, Barry;Hall, Graham
肺功能的测量是常规的年龄较大的儿童和成人囊性纤维化（CF），但不是在婴儿和学龄前儿童。已经确定了与老年受试者相似的幼儿肺部感染、嗜中性粒细胞为主的炎症和临床加重，并强调了在生命早期评估肺功能的迫切需要。越来越多的证据表明，肺功能技术敏感的外周肺功能的变化可能需要检测早期功能异常的婴儿和学龄前儿童CF。此外，大多数在患有CF的幼儿中进行的研究没有报告纵向数据，因此对现有肺功能方法跟踪疾病进展的预后潜力了解甚少。本文综述了最近在婴儿和学龄前儿童中的研究结果，并概述了目前可用的肺功能技术，其标准化的问题及其在婴幼儿CF中的相对优势和劣势。(c)2008爱思唯尔有限公司保留所有权利。
Measurement of lung function is routine in older children and adults with cystic fibrosis (CF) but not in infants and preschool children. Pulmonary 'Infection, neutrophil-dominated inflammation and clinical exacerbations in young children similar to those seen in older subjects have been identified and highlight the urgent need to evaluate lung function in early life. Mounting evidence suggests lung function techniques sensitive to changes in peripheral lung function may be required to detect the early functional abnormalities in infants and preschool children with CF. In addition, the majority of studies in young children with CF have not reported longitudinal data and therefore the prognostic potential of existing lung function methods to track disease progression is poorly understood. This review aims to describe recent research findings in infants and preschool children and to outline currently available lung function techniques, issues around their standardization and their relative advantages and disadvantages in young children with CF. (c) 2008 Elsevier Ltd. All rights reserved.