High-frequency oscillations recorded in human medial temporal lobe during sleep
High-frequency oscillations recorded in human medial temporal lobe during sleep
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DOI：
10.1002/ana.20164
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发表时间：
2004-07-01
影响因子：
11.2
通讯作者：
Engel, J
中科院分区：
文献类型：
--
作者：
Staba, RJ;Wilson, CL;Engel, J
快速涟漪振荡（FR，200- 500 Hz）的存在已在啮齿动物癫痫模型中得到证实，但在非癫痫啮齿动物中尚未观察到，表明FR与癫痫发生相关。虽然在人类癫痫患者中的研究已经报道了FR和波纹（80- 200 Hz）主要发生在非快速眼动睡眠（NREM）期间，并且人类海马中的涟漪振荡类似于在非灵长类动物慢波睡眠中发现的那些，但是以前没有在多导睡眠图定义的睡眠和清醒状态下对这些振荡进行定量研究。使用自动化计算机技术检测内侧颞叶癫痫患者在睡眠和清醒时的自发FR和波纹，结果表明，波纹的发生率，这被认为是代表动物和人类海马的正常活动，癫痫和非癫痫颞叶之间是相似的，而FR的发生率与癫痫区域显着相关。在NREM睡眠期间，FR和波纹的产生率最高。在REM睡眠期间，波动率最低，而FR率保持升高，与清醒期间观察到的频率相当。不仅在NREM睡眠期间，而且在清醒和REM睡眠的癫痫样抑制去兴奋发作期间，致痫区内的FR占主导地位，这支持了FR是与癫痫产生区域相关的病理性神经元超同步化的产物的观点。
The presence of fast ripple oscillations (FRs, 200-500Hz) has been confirmed in rodent epilepsy models but has not been observed in nonepileptic rodents, suggesting that FRs are associated with epileptogenesis. Although studies in human epileptic patients have reported that both FRs and ripples (80-200Hz) chiefly occur during non-rapid eye movement sleep (NREM), and that ripple oscillations in human hippocampus resemble those found in nonprimate slow wave sleep, quantitative studies of these oscillations previously have not been conducted during polysomnographically defined sleep and waking states. Spontaneous FRs and ripples were detected using automated computer techniques in patients with medial temporal lobe epilepsy during sleep and waking, and results showed that the incidence of ripples, which are thought to represent normal activity in animal and human hippocampus, was similar between epileptogenic and nonepileptogenic temporal lobe, whereas rates of FR occurrence were significantly associated with epileptogenic areas. The generation of both FRs and ripples showed the highest rates of occurrence during NREM sleep. During REM sleep, ripple rates were lowest, whereas FR rates remained elevated and were equivalent to rates observed during waking. The predominance of FRs within the epileptogenic zone not only during NREM sleep, but also during epileptiform-suppressing desynchronized episodes of waking and REM sleep supports the view that FRs are the product of pathological neuronal hypersynchronization associated with seizure-generating areas.