Analysis of pulsatile, viscous blood flow through diseased coronary arteries of man.
Analysis of pulsatile, viscous blood flow through diseased coronary arteries of man.
复制标题
分析通过人体患病冠状动脉的脉动粘性血流。
DOI：
10.1016/0021-9290(77)90006-9
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发表时间：
1977
影响因子：
2.4
通讯作者：
D. Crawford
中科院分区：
文献类型：
--
作者：
L. D. Back;J. R. Radbill;D. Crawford
通过使用心动周期中流速的实际变化，对通过动脉部分的脉动粘性血流的流体动力学运动方程进行数值求解，检查了人类主冠状动脉中多个“非阻塞性”斑块的流变效应。计算确定的流动区域包括空间流动加速、减速、分离、重新附着和再发展。流动的血液对内皮表面施加的剪切应力在心动周期中变化很大，并且沿着斑块的剪切应力也有很大的变化。即使在轻微收缩的区域，壁剪应力也相对较大。该计算机程序可以与冠状动脉造影结合使用来研究各种尺寸和形状以及具有可变纵向间距的斑块的流场，以获得壁剪切应力的水平并确定分离的流动区域的存在和范围。
The rheologic effects of multiple “non-obstructive” plaques in main coronary arteries of man were examined by numerically solving the fluid dynamic equations of motion for pulsatile viscous flow of blood through an arterial section using the actual variation of flow rate during the cardiac cycle. Flow regions identified by the calculations include spatial flow acceleration, deceleration, separation, reattachment and redevelopment. Shear stresses exerted by flowing blood on the endothelial surface varied greatly during the cardiac cycle, and there were large variations in shear stress along plaques. Wall shear stresses were relatively large even in regions of mild constriction. The computer program can be utilized in conjunction with coronary angiography to study the flow field for plaques of various sizes and shapes and with variable longitudinal spacing to obtain the level of wall shear stress and to determine the existence and extent of separated flow regions.