Gut microbiota-derived short-chain fatty acids and kidney diseases.
Gut microbiota-derived short-chain fatty acids and kidney diseases.
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DOI：
10.2147/dddt.s150825
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Fu P
中科院分区：
文献类型：
--
作者：
Li L;Ma L;Fu P
肠道菌群及其代谢产物在宿主生理和病理中起着关键作用。短链脂肪酸（SCFAs）作为一组代谢产物，对能量代谢、激素分泌、免疫炎症、高血压和癌症等具有积极的调节作用。SCFAs的功能与其激活跨膜G蛋白偶联受体和抑制组蛋白乙酰化有关。尽管存在争议，但越来越多的证据表明，调节炎症，氧化应激和纤维化的SCFA通过激活肠-肾轴参与肾脏疾病;然而，肠道微生物衍生的代谢产物，信号通路和肾脏疾病之间的分子关系仍有待阐明。本文综述了SCFAs在肾脏疾病中的生理和功能。
Gut microbiota and its metabolites play pivotal roles in host physiology and pathology. Short-chain fatty acids (SCFAs), as a group of metabolites, exert positive regulatory effects on energy metabolism, hormone secretion, immune inflammation, hypertension, and cancer. The functions of SCFAs are related to their activation of transmembrane G protein-coupled receptors and their inhibition of histone acetylation. Though controversial, growing evidence suggests that SCFAs, which regulate inflammation, oxidative stress, and fibrosis, have been involved in kidney disease through the activation of the gut–kidney axis; however, the molecular relationship among gut microbiota–derived metabolites, signaling pathways, and kidney disease remains to be elucidated. This review will provide an overview of the physiology and functions of SCFAs in kidney disease.