Study of combining virtual screening and antiviral treatments of the Sars-CoV-2 (Covid-19)
Study of combining virtual screening and antiviral treatments of the Sars-CoV-2 (Covid-19)
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DOI：
10.1016/j.micpath.2020.104241
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发表时间：
2020-09-01
影响因子：
3.8
通讯作者：
Kafil, Hossein Samadi
中科院分区：
文献类型：
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作者：
Khodadadi, Ehsaneh;Maroufi, Parham;Kafil, Hossein Samadi
最近一种名为SARS-CoV-2的新型人类冠状病毒的流行病爆发，并导致呼吸道疾病COVID-19，已在全球范围内引起共鸣，全球正在努力表征这种病毒的分子特征和进化起源。因此，快速准确地鉴定致病病毒对于选择适当的治疗方法，挽救人们的生命和预防流行病起着至关重要的作用。此外，一般治疗，冠状病毒特异性治疗和抗病毒治疗可用于对抗COVID-19。本文综述了SARS-CoV-2与宿主受体的相互作用，以及利用免疫信息学方法鉴定SARS-CoV-2表面糖蛋白的T细胞表位。还开发了各种改进的或新的方法。预计这将有助于研究人员和临床医生开发更好的技术，以及时有效地检测冠状病毒感染。此外，可获得导致COVID-19的病毒的基因组序列以及实验确定的主要蛋白酶（Mpro）的三维结构。在本综述中描述了所报道的靶点Mpro的结构，以使用虚拟高通量筛选来鉴定用于COVID-19的潜在药物。
The recent epidemic outbreak of a novel human coronavirus called SARS-CoV-2 and causing the respiratory tract disease COVID-19 has reached worldwide resonance and a global effort is being undertaken to characterize the molecular features and evolutionary origins of this virus. Therefore, rapid and accurate identification of pathogenic viruses plays a vital role in selecting appropriate treatments, saving people's lives and preventing epidemics. Additionally, general treatments, coronavirus-specific treatments, and antiviral treatments useful in fighting COVID-19 are addressed. This review sets out to shed light on the SARS-CoV-2 and host receptor recognition, a crucial factor for successful virus infection and taking immune-informatics approaches to identify Band T-cell epitopes for surface glycoprotein of SARS-CoV-2. A variety of improved or new approaches also have been developed. It is anticipated that this will assist researchers and clinicians in developing better techniques for timely and effective detection of coronavirus infection. Moreover, the genomic sequence of the virus responsible for COVID-19, as well as the experimentally determined three-dimensional structure of the Main protease (Mpro) is available. The reported structure of the target Mpro was described in this review to identify potential drugs for COVID-19 using virtual high throughput screening.