Outbreaks of disease suspected of being due to human monkeypox virus infection in the Democratic Republic of Congo in 2001
Outbreaks of disease suspected of being due to human monkeypox virus infection in the Democratic Republic of Congo in 2001
复制标题
DOI：
10.1128/jcm.40.8.2919-2921.2002
复制
发表时间：
2002-08-01
影响因子：
9.4
通讯作者：
Formenty, P
中科院分区：
文献类型：
--
作者：
Meyer, H;Perrichot, M;Formenty, P
对7起以脓疱性皮疹为特征的疑似由人猴痘病毒引起的疾病暴发进行了调查。2001年2月至8月期间在刚果民主共和国赤道省爆发。这些爆发共涉及31人，造成5人死亡。从14例患者的标本，并进行了分析，电子显微镜，病毒分离，特异性猴痘病毒和水痘带状疱疹病毒的PCR检测。我们提供的证据表明，两次暴发确实是由猴痘病毒引起的（16例，4例死亡），两次暴发涉及猴痘和水痘-带状疱疹病毒（7例，1例死亡），两次暴发是由水痘-带状疱疹病毒感染引起的水痘病例（6例，无死亡）。在一次暴发中，没有发现猴痘或水痘的证据（两例，无死亡）。
Seven outbreaks of disease characterized by a pustular rash and suspected to have been caused by human monkeypox virus were investigated. The outbreaks occurred between February and August 2001 in the province of Equateur in the Democratic Republic of Congo. The outbreaks involved a total of 31 persons and caused five deaths. Specimens from 14 patients were available and were analyzed by electron microscopy, virus isolation, and PCR assays specific for monkeypox virus and varicella-zoster virus. We provide evidence that two outbreaks were indeed caused by monkeypox virus (16 cases, with four deaths), that in two outbreaks both monkeypox and varicella-zoster virus were involved (seven cases, with one death), and that two outbreaks were cases of chickenpox caused by infection with varicella-zoster virus (six cases, with no deaths). In one outbreak, no evidence for either monkeypox or chickenpox was found (two cases, with no deaths).