Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT: final results after a 5-year screening programme
Smoking habits in the randomised Danish Lung Cancer Screening Trial with low-dose CT: final results after a 5-year screening programme
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DOI：
10.1136/thoraxjnl-2013-203849
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发表时间：
2014-06-01
期刊：
影响因子：
10
通讯作者：
Tonnesen, Philip
中科院分区：
文献类型：
--
作者：
Ashraf, Haseem;Saghir, Zaigham;Tonnesen, Philip
在一项为期5年的筛查试验中，我们提出了肺癌低剂量CT筛查对参与者吸烟习惯影响的最终结果。方法丹麦肺癌筛查试验（DLCST）是一项为期5年的筛查试验，纳入4104名受试者；2052例随机分为每年低剂量CT组（CT组）和不干预组（对照组）。参与者是当前吸烟者和戒烟者（>=戒烟4周），烟草消费量>= 20包年。每年确定吸烟习惯。在最后一轮筛选中，吸烟状况的缺失值使用两种不同的模型进行处理。结果CT组与对照组年吸烟状况比较，差异无统计学意义。总体而言，CT +对照组的戒烟率在筛查的第5年从24%（基线）显著增加到37% (p
Background We present the final results of the effect of lung cancer screening with low-dose CT on the smoking habits of participants in a 5-year screening trial.Methods The Danish Lung Cancer Screening Trial (DLCST) was a 5-year screening trial that enrolled 4104 subjects; 2052 were randomised to annual low-dose CT (CT group) and 2052 received no intervention (control group). Participants were current and ex-smokers (>= 4 weeks abstinence from smoking) with a tobacco consumption of >= 20 pack years. Smoking habits were determined annually. Missing values for smoking status at the final screening round were handled using two different models.Results There were no statistically significant differences in annual smoking status between the CT group and control group. Overall the ex-smoker rates (CT + control group) significantly increased from 24% (baseline) to 37% at year 5 of screening (p