ASPECTS OF OXYGEN AND GLUCOSE CONSUMPTION IN THE RETINA - EFFECTS OF HIGH INTRAOCULAR-PRESSURE AND LIGHT
ASPECTS OF OXYGEN AND GLUCOSE CONSUMPTION IN THE RETINA - EFFECTS OF HIGH INTRAOCULAR-PRESSURE AND LIGHT
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DOI：
10.1007/bf02764305
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发表时间：
1990-01-01
影响因子：
2.7
通讯作者：
SPERBER, GO
中科院分区：
文献类型：
--
作者：
BILL, A;SPERBER, GO
综述了猫和猪视网膜氧和葡萄糖消耗的研究，并介绍了最近在猴子身上进行的脱氧葡萄糖方法的实验。在这三种动物中，视网膜和脉络膜血管都为视网膜提供营养。对猫局部血流和动静脉浓度差异的研究表明，在全身麻醉和实验室光照条件下，脉络膜供氧约为5.6微升/分，视网膜血管供氧约为1.3微升/分。在猪中，相应的数字分别约为4微升/分钟和2.9微升/分钟。由于视网膜血流量的有效自动调节，由于眼压升高或动脉血压降低而引起的灌流压力的适度降低，导致视网膜内部的氧分压几乎没有变化。脉络膜血流量的减少在很大程度上被动静脉浓度的增加所补偿。在猴子身上使用脱氧葡萄糖方法的研究表明，戊巴比妥麻醉和持续照明往往会降低视网膜的新陈代谢。在黑暗条件下，光感受器的葡萄糖消耗高于白光恒定光照条件下记录的葡萄糖消耗。4赫兹的闪烁光增加了视网膜内部的葡萄糖消耗。在非常高的眼压下，视网膜的葡萄糖消耗增加，这可能是部分缺血的结果，并转变为更多的无氧葡萄糖代谢。
Studies on retinal oxygen and glucose consumption in cats and pigs are reviewed and recent experiments with the deoxyglucose method in monkeys are described. In all three species, the retina is supplied with nutrients by both the retinal and the choroidal blood vessels. Studies on regional blood flow and differences in arteriovenous concentration in cats have indicated that under conditions of general anesthesia and exposure to laboratory light, the oxygen supply from the choroid is about 5.6 .mu.l/min and that from the retinal vessels, 1.3 .mu.l/min. In pigs the corresponding figures were about 4 and 2.9 .mu.l/min, respectively. Moderate reductions in perfusion pressure caused by increments in intraocular pressure or reductions in arterial blood pressure resulted in little change in oxygen tension in the inner retina, due to efficient autoregulation of retinal blood flow. Reduced choroidal blood flow was to a large extent compensated by increased differences in arteriovenous concentration. Studies using the deoxyglucose method in monkeys indicated that pentobarbital anesthesia and constant illumination tend to reduce the metabolism of the retina. In darkness, glucose consumption in the photoreceptors was higher than that recorded under conditions of constant illumination with white light. Flickering light at 4 Hz enhanced glucose consumption in the inner retina. At very high intraocular pressures glucose consumption in the retina was enhanced, probably as a result of partial ischemia, with a shift to more anaerobic glucose metabolism.