Direct immunofluorescent studies of pemphigus and bullous pemphigoid.
Direct immunofluorescent studies of pemphigus and bullous pemphigoid.
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天疱疮和大疱性类天疱疮的直接免疫荧光研究。
DOI：
10.1001/archderm.1971.04000170020004
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发表时间：
1971
影响因子：
--
通讯作者：
A. L. Schroeter
中科院分区：
文献类型：
--
作者：
Robert E. Jordan;C. Triftshauser;A. L. Schroeter
采用针对人IgG、IgA、IgM和β 1c /β 1a球蛋白的特异性抗血清，对皮肤病（包括大疱性皮肤病）患者的皮肤活检标本进行直接免疫荧光（IF）染色。在大疱性类天疱疮患者皮损的基底膜区一致发现IgG和补体C′。大疱性类天疱疮的直接IF染色阳性可能具有相当大的诊断意义，特别是在没有明显循环抗体的情况下。在天疱疮患者病变的细胞间质区一致观察到IgG，而未检测到C'。IgA和IgM仅在少数情况下出现，在这两种疾病中似乎都没有什么意义。进行了涉及自身反应性的特殊研究。
Direct immunofluorescent (IF) staining was carried out on skin biopsy specimens of patients with skin diseases (including bullous skin diseases), with use of specific antisera to human IgG, IgA, IgM, and β 1 C/β 1 A globulin. IgG and complement (C') were consistently found in the basementmembrane-zone area in skin lesions of patients with bullous pemphigoid. Positive direct IF staining in bullous pemphigoid may assume considerable diagnostic importance, especially in cases without demonstrable circulating antibody. IgG was consistently observed in the intercellular-substance areas in lesions of patients with pemphigus, whereas C' was not detected. IgA and IgM, encountered in a few instances only, appear to have little, if any, significance in either disease. Special studies, involving autoreactivity, were done.