Predilection of a nasopharyngeal carcinoma-derived isolate of Epstein-Barr virus for infection of specific subsets of B lymphocytes.
Predilection of a nasopharyngeal carcinoma-derived isolate of Epstein-Barr virus for infection of specific subsets of B lymphocytes.
复制标题
鼻咽癌衍生的 Epstein-Barr 病毒分离株倾向于感染特定的 B 淋巴细胞亚群。
DOI：
10.1002/jmv.1890290109
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发表时间：
1989
影响因子：
12.7
通讯作者：
Glaser,R
中科院分区：
文献类型：
--
作者：
Tarr,KL;Glaser,R
It is important to know whether there are variants of Epstein‐Barr virus (EBV) with biological properties that are different from the prototype viruses that have been studied in detail, such as P3HR‐1 and B95‐8. We have studied an EBV isolate derived from a nasopharyngeal carcinoma (NPC) tumor, designated NPC‐EBV. We have examined the target B lymphocytes infected and growth‐transformed with NPC‐EBV as compared with two common EBV isolates, B95‐8 and AG876 EBV, for stage of maturation using antibodies to several immunoglobulin chains. Typing of the NPC‐EBV transformed lymphoblastoid cell lines revealed the predilection of the NPC‐EBV isolate to infect immature B lymphocytes. This was not the case for the B95‐8 and AG876 isolates. The reason for the predilection of NPC‐EBV for immature B lymphocytes remains to be explored further. However, these results may be important in understanding the pathophysiology of EBV‐associated diseases.
