Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors
Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptors
复制标题
DOI：
10.1091/mbc.12.2.449
复制
发表时间：
2001-02-01
影响因子：
3.3
通讯作者：
Stachowiak, MK
中科院分区：
文献类型：
--
作者：
Peng, H;Moffett, J;Stachowiak, MK
在牛肾上腺髓质细胞中，协同作用的1型和2型血管紧张素II（AII）受体通过独特的AII响应启动子元件激活成纤维细胞生长因子-2（FGF-2）基因。I型和2型All受体以及下游环腺苷1 '，3'-单磷酸和蛋白激酶C依赖性信号传导途径通过新的信号转导机制激活FGF-2启动子。这种机制，我们已经命名为整合核FGF受体-1信号，涉及FGF受体-1的核转位及其随后的反式激活的AII反应元件的FGF-2启动子。
In bovine adrenal medullary cells synergistically acting type 1 and type 2 angiotensin II (AII) receptors activate the fibroblast growth factor-2 (FGF-2) gene through a unique AII-responsive promoter element. Both the type I and type 2 All receptors and the downstream cyclic adenosine 1',3'-monophosphate- and protein kinase C-dependent signaling pathways activate the FGF-2 promoter through a novel signal-transducing mechanism. This mechanism, which we have named integrative nuclear FGF receptor-1 signaling, involves the nuclear translocation of FGF receptor-1 and its subsequent transactivation of the AII-responsive element in the FGF-2 promoter.