Molecular Koch's postulates applied to microbial pathogenicity.
Molecular Koch's postulates applied to microbial pathogenicity.
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DOI：
10.1093/cid/10.supplement_2.s274
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发表时间：
1988-08
期刊：
影响因子：
--
通讯作者：
S. Falkow
中科院分区：
文献类型：
--
作者：
S. Falkow
微生物遗传学和分子克隆技术使我们能够常规地从各种微生物病原体中分离出特定的基因。显然，并非所有来自病原微生物的基因都在致病性或毒力中起作用。正如科赫假设是为了确定生物体和特定疾病之间的因果关系而制定的，这里提出的概念是，当检查基因及其产物在感染和疾病的发病机制中的潜在作用时，需要一种分子科赫假设。
Microbial genetics and molecular cloning now permit us to routinely isolate specific genes from a variety of microbial pathogens. Obviously not all genes from pathogenic microorganisms play a role in pathogenicity or virulence. Just as Koch's postulates were formulated to identify the causal relationship between an organism and a specific disease, the notion is presented here that a form of molecular Koch's postulates is needed when examining the potential role of genes and their products in the pathogenesis of infection and disease.