Measuring exhaled nitric oxide levels in adults -: The importance of atopy and airway responsiveness
Measuring exhaled nitric oxide levels in adults -: The importance of atopy and airway responsiveness
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DOI：
10.1378/chest.126.5.1540
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发表时间：
2004-11-01
期刊：
影响因子：
9.6
通讯作者：
Turner, SW
中科院分区：
文献类型：
--
作者：
Franklin, PJ;Stick, SM;Turner, SW
背景：呼出一氧化氮（FENO）水平升高与哮喘有关。然而，我们发现，在儿童中，气道反应性 (AIR) 增加的特应性儿童中 FENO 增加，这与哮喘的诊断无关。研究目标：本研究旨在检验成人中在控制特应性和 AIR 后，FENo 与哮喘之间没有关联的假设。测量：115 名成人（77 名女性；平均年龄，41 岁）接受了评估，包括 FENO 测量、肺活量测定、皮肤点刺测试、血液检查嗜酸性粒细胞计数和吸入组胺激发（结果表示为剂量反应斜率 [DRS]）。结果：当仅考虑特应性个体时 (n = 73)，FENO 与 DRS (p = 0.003)、男性 (0.02) 呈正相关，与当前吸烟呈负相关 (p = 0.09)。在非特应性个体 (n = 36) 中，只有男性 (p = 0.03) 与 FENo 相关。在多变量分析中，FENo 与当前哮喘、当前喘息或曾经患有哮喘之间没有关联。结论：我们的结论是，在成人受试者中，FENO 测量值升高与特应性和 AR 增加的表型相关，无论是否存在哮喘或哮喘样症状。
Background: Raised exhaled nitric oxide (FENO) levels have been associated with asthma. However, we have found that in children, FENO was increased in atopic children with increased airway responsiveness (AIR), and this was independent of a diagnosis of asthma.Study objectives: The current study was designed to test the hypothesis that in adults there is no association between FENo and asthma after controlling for atopy and AIR.Measurements: One hundred fifteen adults (77 women; mean age, 41 years) underwent an assessment that included FENO measurements, spirometry, skin-prick testing, blood eosinophil count, and inhaled histamine challenge (results are expressed as a dose-response slope [DRS]). Results: When only atopic individuals were considered (n = 73), FENO was positively associated with the DRS (p = 0.003), male gender (0.02), and negatively associated with current smoking (p = 0.09). Only male gender (p = 0.03) was associated with FENo among nonatopic individuals (n = 36). In multivariate analysis, there was no association between FENo and current asthma, current wheeze, or asthma ever.Conclusions: We conclude that in adult subjects, elevated FENO measurements are associated with a phenotype characterized by atopy and increased AR regardless of the presence of asthma or asthma-like symptoms.