Distributed Drug Discovery, Part 1: linking academia and combinatorial chemistry to find drug leads for developing world diseases.
Distributed Drug Discovery, Part 1: linking academia and combinatorial chemistry to find drug leads for developing world diseases.
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DOI：
10.1021/cc800183m
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发表时间：
2009-01
影响因子：
--
通讯作者：
O'Donnell, Martin J.
中科院分区：
文献类型：
--
作者：
Scott, William L.;O'Donnell, Martin J.
仍然需要创新和廉价的药物来治疗发展中世界的疾病。1，2将学术培训和研究与关键的社会需求联系起来也很重要。印第安纳州普渡大学印第安纳波利斯分校（IUPUI）正在通过开发一种称为“分布式药物发现”（D3）的概念来解决这两个问题。3这个观点描述了D3如何利用分布在多个学术和工业地点的组合化学来教育学生，同时他们在发展中国家和其他被忽视的疾病的药物先导发现的早期阶段发挥关键作用。本期《组合化学杂志》的另外两篇文章介绍了实现D3化学成分的案例。一个涉及在美国、波兰、俄罗斯和西班牙复制的D3合成。第二个是IUPUI的学生制作潜在抗癌剂的类似物的应用。[5]从这个角度来看，D3分三个部分讨论：（I）D3的概念，（II）组合化学在D3中的作用，（III）D3的实现。
There continues to be a need for innovative and inexpensive drugs to treat diseases of the developing world. 1, 2 It is also important to link academic training and research to critical societal needs. Indiana University-Purdue University Indianapolis (IUPUI) is addressing both these concerns by developing a concept called “Distributed Drug Discovery”(D3). 3 This Perspective describes how D3 can harness combinatorial chemistry, distributed over multiple academic and industrial locations, to educate students while they perform a key role in the early stages of drug lead discovery for developing world and otherwise neglected diseases. Two other articles in this issue of the Journal of Combinatorial Chemistry present case histories implementing the chemistry component of D3. One involves replicated D3 syntheses in the United States, Poland, Russia, and Spain. 4 The second is an application in which students at IUPUI make analogs of a potential anticancer agent. 5 In this Perspective, D3 is discussed in three parts:(I) The Concept of D3,(II) The Role of Combinatorial Chemistry in D3, and (III) Implementation of D3.
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影响因子：
3
作者：
Birkholtz LM;Bastien O;Wells G;Grando D;Joubert F;Kasam V;Zimmermann M;Ortet P;Jacq N;Saïdani N;Roy S;Hofmann-Apitius M;Breton V;Louw AI;Maréchal E
通讯作者：
Maréchal E
影响因子：
3.6
作者：
Boojamra, CG;Burow, KM;Ellman, JA
通讯作者：
Ellman, JA
影响因子：
15.8
作者：
Benatar SR
通讯作者：
Benatar SR
影响因子：
1.5
作者：
Borman, S
通讯作者：
Borman, S
DOI：
10.2471/blt.06.029843
发表时间：
2006-05-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Chokshi, Dave A;Parker, Michael;Kwiatkowski, Dominic P
通讯作者：
Kwiatkowski, Dominic P