Influence of optic disc size on the sensitivity of the Heidelberg Retina Tomograph
Influence of optic disc size on the sensitivity of the Heidelberg Retina Tomograph
复制标题
视盘大小对海德堡视网膜断层扫描仪灵敏度的影响
DOI：
10.1007/s004170050135
复制
发表时间：
1998
期刊：
影响因子：
--
通讯作者：
F. Horn
中科院分区：
文献类型：
--
作者：
C. Mardin;F. Horn
摘要·目的：本研究的目的是在横断面研究中评估视盘大小对Heidelberg视网膜断层成像（软件版本1.11）产生的变量区分青光眼患者和正常人能力的影响。·患者和方法：选择87只正常眼和61只青光眼，用海德堡视网膜断层扫描对视盘进行评价。选取视盘面积、参考上方体积、边缘面积、杯面积、杯体积、轮廓第三矩和视盘边缘视网膜神经纤维层平均厚度进行评价。这些变量在80%特异性下的敏感性是在三种情况下计算的：(1)不校正椎间盘大小；(2)下列阀瓣尺寸范围的计算：I级（1.0-2.0 mm²），II级（2.0-2.5 mm²），III级（2.5-3.15 mm²）和IV级（3.15-5.0 mm²）；(3)全局计算，考虑到四类圆盘大小的不同。·结果：正常人神经视网膜边缘面积、杯面积和体积、第三矩、神经纤维层厚度与视盘大小呈显著正相关。神经视网膜边缘体积测量在统计学上与视盘大小无关。当不考虑视盘的大小时，灵敏度最低。当评估四种视盘大小时，灵敏度增加。随着视盘尺寸的增大，视网膜神经纤维层的敏感度增加，第三矩值降低。杯的体积和面积对大的视盘敏感度最低。在所有三种情况下，神经视网膜边缘的面积是唯一显示相似灵敏度值的变量。·结论：HRT变量的敏感性随视盘大小而变化。评估其灵敏度需要定义视盘类别或对视盘大小进行统计校正。
Abstract · Purpose: The aim of this study was to evaluate the influence of optic disc size on the ability of variables generated by the Heidelberg Retina Tomograph, software version 1.11, to distinguish glaucoma patients from normals in a cross-sectional study. · Patients and methods: For evaluation of the optic disc with the Heidelberg Retina Tomograph, eyes of 87 normals and 61 glaucoma patients were selected. Disc area, volume above reference, rim area, cup area, cup volume, third moment in contour and the mean retinal nerve fibre layer thickness at the border of the optic disc were selected for evaluation. The sensitivity at 80% specificity of these variables was calculated under three conditions: (1) no correction for disc size; (2) calculation in the following disc size ranges: class I (1.0–2.0 mm²), class II (2.0–2.5 mm²), class III (2.5–3.15 mm²) and class IV (3.15–5.0 mm²); (3) calculation globally, taking into account the different disc sizes of the four classes. · Results: Neuroretinal rim area, cup area and volume, third moment and nerve fibre layer thickness were significantly and positively correlated with optic disc size in normals. Neuroretinal rim volume measurements were statistically independent of optic disc size. Sensitivity was lowest when the size of the optic disc was not considered. Sensitivity increased when evaluated in four optic disc size classes. With growing optic disc size sensitivity of the retinal nerve fibre layer increased and third moment value decreased. Cup volume and area had their lowest sensitivity for large optic discs. The area of the neuroretinal rim was the only variable which showed similar sensitivity values under all three conditions. · Conclusions: The sensitivities of HRT variables varied with optic disc size. Evaluation of their sensitivity requires the definition of optic disc classes or statistical correction for the size of the optic disc.