A new mechanism for collective migration in Myxococcus xanthus
A new mechanism for collective migration in Myxococcus xanthus
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DOI：
10.1007/s10955-007-9298-9
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发表时间：
2007-07-01
影响因子：
1.6
通讯作者：
Deutsch, A.
中科院分区：
文献类型：
--
作者：
Starruss, J.;Bley, Th.;Deutsch, A.
粘细菌具有复杂的生命周期，其特征是一系列细胞模式，最终形成三维子实体。本文提供的迹象表明，特定的细胞形状的粘细菌可能在不同的生活史的形态发生过程中发挥重要作用。我们介绍了一种新的集体迁移机制，可以解释在粘细菌对齐的细胞簇的形成。该机制不依赖于细胞间的相互协作，尤其不依赖于扩散信号引导细胞的运动，提出了一个描述粘细菌杆状细胞形状、细胞刚度和主动运动的细胞Potts模型（CPM）。通过对模型细胞群体的数值模拟，其中细胞通过体积排阻相互作用，我们提供了集体迁移的纯机械机制的证据，该机制由细胞的长宽比控制。
Myxobacteria exhibit a complex life cycle characterized by a sequence of cell patterns that culminate in the formation of three-dimensional fruiting bodies. This paper provides indications that the specific cell shape of myxobacteria might play an important role in the different morphogenetic processes during the life cycle. We introduce a new mechanism for collective migration that can explain the formation of aligned cell clusters in myxobacteria. This mechanism does not depend on cell cooperation, and in particular it does not depend on diffusive signals guiding cell motion.A Cellular Potts Model (CPM) that captures the rod cell shape, cell stiffness and active motion of myxobacteria is presented. By means of numerical simulations of model cell populations where cells interact via volume exclusion, we provide evidence of a purely mechanical mechanism for collective migration, which is controlled by the cells' length-to-width aspect ratio.