Influenza-induced innate immunity: regulators of viral replication, respiratory tract pathology & adaptive immunity.
Influenza-induced innate immunity: regulators of viral replication, respiratory tract pathology & adaptive immunity.
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DOI：
10.2217/fvl.11.63
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发表时间：
2011-08
期刊：
影响因子：
3.1
通讯作者：
Baumgarth N
中科院分区：
文献类型：
--
作者：
Oslund KL;Baumgarth N
流感病毒感染通常会导致轻度至中度严重的呼吸道疾病，但有些感染，如涉及禽H5N1病毒的感染，可导致大规模病毒性肺炎，全身性疾病和死亡。呼吸道驻留细胞的先天免疫应答是第一道防线，限制病毒复制。然而，感染后细胞因子和趋化因子的产生增强似乎是高致病性菌株感染后发生的大部分病理的基础。所谓的“细胞因子风暴”可损害肺组织并引起全身性疾病，尽管病毒复制受到控制。通过总结目前对流感感染的先天性反应的认识，本文综述了呼吸道上皮细胞作为流感病毒先天性和适应性免疫调节因子的重要性。
Influenza virus infections usually cause mild to moderately severe respiratory disease, however some infections, like those involving the avian H5N1 virus, can cause massive viral pneumonia, systemic disease and death. The innate immune response of respiratory tract resident cells is the first line of defense and limits virus replication. Enhanced cytokine and chemokine production following infection, however, appears to underlie much of the pathology that develops after infection with highly pathogenic strains. A so-called `cytokine storm' can damage the lung tissue and cause systemic disease, despite the control of viral replication. By summarizing current knowledge of the innate responses mounted to influenza infection, this review highlights the importance of the respiratory tract epithelial cells as regulators of innate and adaptive immunity to influenza virus.