Left Amygdala Regulates the Cerebral Reading Network During Fast Emotion Word Processing
Left Amygdala Regulates the Cerebral Reading Network During Fast Emotion Word Processing
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DOI：
10.3389/fpsyg.2020.00001
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发表时间：
2020-01
影响因子：
3.8
通讯作者：
Kimihiro Nakamura;Tomoe Inomata;A. Uno
中科院分区：
文献类型：
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作者：
Kimihiro Nakamura;Tomoe Inomata;A. Uno
情感词是一类特殊的言语刺激，它能迅速激活左半球语言网络之外的边缘系统。这种对情绪词的快速反应可能独立于参与视觉词形分析的左枕颞区，并依赖于参与恐惧面孔处理的独特的杏仁核依赖性情绪回路。本研究采用半场启动范式结合功能磁共振成像，探讨了情绪词加工过程中左右杏仁核系统与阅读网络的相互作用。在每一次试验中，参与者都看到了一个中央呈现的目标，之前有一个掩蔽的启动闪烁到左侧或右侧视野。启动词和目标词分别表示否定名词和肯定名词，它们既可以是情感一致的，也可以是情感不一致的。我们观察到，情感一致性产生了平行的变化，在左侧额叶和顶颞区和双侧杏仁核之间的神经启动。然而，我们也发现，左侧杏仁核，而不是右侧，表现出显着的功能连接的阅读的神经成分的情感一致性的功能变化。总的来说，这些结果表明，情绪词激活双边杏仁核在情绪词处理的早期阶段，而只有左侧杏仁核施加长距离的调节影响，通过其强大的半球内连接的阅读网络。
Emotion words constitute a special class of verbal stimuli which can quickly activate the limbic system outside the left-hemisphere language network. Such fast response to emotion words may arise independently of the left occipitotemporal area involved in visual word-form analysis and rely on a distinct amygdala-dependent emotion circuit involved in fearful face processing. Using a hemifield priming paradigm with fMRI, we explored how the left and right amygdala systems interact with the reading network during emotion word processing. On each trial, participants viewed a centrally presented target which was preceded by a masked prime flashed either to the left or right visual field. Primes and targets, each denoting negative or positive nouns, could be either affectively congruent or incongruent with each other. We observed that affective congruency produced parallel changes in neural priming between the left frontal and parietotemporal regions and the bilateral amygdala. However, we also found that the left, but not right, amygdala exhibited significant change in functional connectivity with the neural components of reading as a function of affective congruency. Collectively, these results suggest that emotion words activate the bilateral amygdala during early stages of emotion word processing, whereas only the left amygdala exerts a long-distance regulatory influence over the reading network via its strong within-hemisphere connectivity.