Clinical and Pathologic Features and Prognostic Factors for Recurrent Gliomas
Clinical and Pathologic Features and Prognostic Factors for Recurrent Gliomas
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DOI：
10.1016/j.wneu.2019.02.210
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发表时间：
2019-08-01
影响因子：
2
通讯作者：
Mao, Qing
中科院分区：
文献类型：
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作者：
Li, Jiaoming;Niu, Xiaodong;Mao, Qing
目的：目的：探讨影响脑胶质瘤复发时间及预后的相关因素。方法：回顾性分析2009 - 2018年在华西医院首次手术治疗并复发的脑胶质瘤患者的病理及临床资料。回顾患者的临床特征，并进行生存分析，以确定复发时间的预后因素。结果：共84例符合纳入标准的患者纳入本研究，其他相关因素在综合分析中也被详细考虑。通过配对样本的统计学分析确定O-6-甲基鸟嘌呤-DNA甲基转移酶（阳性/阴性）、异柠檬酸脱氢酶1（阳性/阴性）和Ki-67之间的显著差异（P = 0.013，P = 0.014，P = 0.017）。单因素分析显示Ki-67（低表达、中表达、高表达）、初始世界卫生组织分级（低或高）、肿瘤侧（左、右、中）、年龄（>= 50岁，
OBJECTIVE: To explore related factors that influence time to recurrence and prognosis of gliomas.METHODS: A retrospective analysis of pathologic and clinical data of patients with glioma who underwent surgery for the first time and had a recurrence between 2009 and 2018 in West China Hospital was performed. Clinical characteristics of patients were reviewed, and survival analysis was performed to identify prognostic factors for the recurrent time. Molecules with differential changes in the paired samples were included in the survival analysis.RESULTS: A total of 84 patients met our inclusion requirements and were included in the study; other related factors were also considered in detail in the integrated analysis. Significant differences among O-6-methylguanine-DNA methyltransferase (positive/negative), isocitrate dehydrogenase 1 (positive/negative), and Ki-67 were determined by statistical analysis of paired samples (P = 0.013, P = 0.014, P = 0.017). Univariate analysis demonstrated that Ki-67 (low expression, medium expression, high expression), initial World Health Organization grade (low or high), tumor side (left, right, middle), age (>= 50 years,