Study of parathyroid function in man by EDTA infusion.
Study of parathyroid function in man by EDTA infusion.
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通过 EDTA 输注研究人类甲状旁腺功能。
DOI：
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发表时间：
1969
影响因子：
5.8
通讯作者：
A. Parfitt
中科院分区：
文献类型：
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作者：
A. Parfitt
在2名正常人、4名假性甲状旁腺功能减退症患者和15名接受颈部手术的患者（11名随后发生暂时性低钙血症，4名未发生）中研究了对Na 3 EDTA输注2小时的反应。为了建立非任意的解释标准，这21例病例和129例其他病例报告，根据他们在测试前的状态分为3组：i）64例正常人，ii）57例既往无甲状旁腺功能障碍证据（除甲状腺功能亢进治疗外），iii）29例既往有甲状旁腺功能障碍证据。校正至输注前水平10.0 mg/100 ml的未螯合血浆钙平均值显示，输注结束（时间0）后10小时（C10）组i和ii之间以及输注结束后22小时（C22）组ii和iii之间存在显著（p<0.001）差异。根据这些结果，定义了3个反应等级，并根据该等级对本研究中的21例病例进行了重新分类：0级（正常）-C22和C10均≥9.5 mg/100 ml（5/21例），g...
ABSTRACT The response to a 2-hr infusion of Na3 EDTA was studied in 2 normals, 4 patients with pseudohypoparathyroidism and 15 patients who had undergone neck surgery, 11 with subsequent temporary hypocalcemia and 4 without. To establish non-arbitrary criteria of interpretation, these 21 cases and 129 others reported, were divided into 3 groups according to their status before the test: i) 64 normals, ii) 57 without prior evidence of parathyroid dysfunction other than treatment for hyperthyroidism, and iii) 29 with prior evidence of parathyroid dysfunction. The mean values of unchelated plasma calcium corrected to a preinfusion level of 10.0 mg/100 ml showed significant (p<0.001) differences between groups i and ii at 10 hr (C10) and between groups ii and iii at 22 hr (C22) after the end of the infusion (Time 0). Based on these results, 3 grades of response were defined, according to which the 21 cases in the present study were reclassified: grade 0 (normal)—C22 and C10 both ≥9.5 mg/100 ml (5/21 cases), g...