THE MHC CLASS-I HOMOLOG ENCODED BY HUMAN CYTOMEGALOVIRUS BINDS ENDOGENOUS PEPTIDES
THE MHC CLASS-I HOMOLOG ENCODED BY HUMAN CYTOMEGALOVIRUS BINDS ENDOGENOUS PEPTIDES
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DOI：
10.1016/1074-7613(95)90129-9
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发表时间：
1995-11-01
期刊：
影响因子：
32.4
通讯作者：
BJORKMAN, PJ
中科院分区：
文献类型：
--
作者：
FAHNESTOCK, ML;JOHNSON, JL;BJORKMAN, PJ
研究了人巨细胞病毒编码的MHC I类分子同源物作为肽受体的能力。从纯化的病毒蛋白中洗脱的肽物质测序显示，内源性肽的混合物具有与传统I类分子洗脱的肽相似的特征，即锚定残基，以及来自细胞质蛋白的短肽的优势。这种病毒MHC同源物的可能功能根据它结合内源性肽的发现进行了讨论。
The ability of a human cytomegalovirus-encoded homolog of MHC class I molecules to serve as a peptide receptor was investigated. Sequencing of peptide material eluted from the purified viral protein revealed a mixture of endogenous peptides with characteristics similar to those eluted from conventional class I molecules, that is, anchor residues, and a predominance of short peptides derived from cytoplasmic proteins. The possible function(s) of this viral MHC homolog are discussed in light of the finding that it binds endogenous peptides.