Subclinical carotid artery disease and plasma homocysteine levels in patients with hypertension
Subclinical carotid artery disease and plasma homocysteine levels in patients with hypertension
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DOI：
10.1016/j.jash.2014.12.020
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发表时间：
2015-03-01
影响因子：
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通讯作者：
Sechi, Leonardo A.
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文献类型：
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作者：
Catena, Cristiana;Colussi, GianLuca;Sechi, Leonardo A.
有关同型半胱氨酸 (Hcy) 水平与亚临床颈动脉疾病之间关联的信息有限。我们研究了高血压患者血浆 Hcy 浓度与颈动脉斑块和内膜中层厚度 (IMT) 的关系。在 486 名接受颈动脉超声检查的原发性高血压患者中，我们测量了 Hey、维生素 B12、叶酸和 C 反应蛋白的血浆水平。 34% 的研究患者中检测到牙菌斑。有颈动脉斑块证据的高血压患者的血浆Hey水平显着高于没有颈动脉斑块的高血压患者。颈动脉 IMT 在血浆 Hey 水平的四分位范围内逐渐增加。多因素回归显示颈动脉IMT与年龄独立相关；血压、C 反应蛋白和 Hcy 水平。在逻辑回归中，年龄、血压、甘油三酯和 Hcy 独立预测颈动脉斑块的存在。因此，血浆 Hcy 水平升高与高血压患者的无症状颈动脉疾病相关，表明 Hcy 在这些患者颈动脉粥样硬化的发生和进展中发挥作用。 (C) 2015 年美国高血压学会。版权所有。
Information on the association between homocysteine (Hcy) levels and subclinical carotid artery disease is limited. We investigated the relationship of plasma Hcy concentration with carotid artery plaques and intima-media thickness (IMT) in patients with hypertension. In 486 essential hypertensive patients who underwent ultrasound examination of the carotid arteries, we measured plasma levels of Hey, vitamin B12, folate, and C-reactive protein. Plaques were detected in 34% of the study patients. Plasma Hey levels were significantly greater in hypertensive patients with evidence of carotid plaques than patients without carotid plaques. Carotid IMT progressively increased across quartiles of plasma Hey levels. Multivariate regression showed that carotid IMT was independently related with age; blood pressure, C-reactive protein, and Hcy levels. In a logistic regression, age, blood pressure, triglyceride, and Hcy independently predicted the presence of carotid plaques. Thus, elevated plasma Hcy levels are associated with asymptomatic carotid disease in hypertensive patients suggesting a role of Hcy in the development and progression of carotid atherosclerosis in these patients. (C) 2015 American Society of Hypertension. All rights reserved.