A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies.
A strongly selected mutation in the HIV-1 genome is independent of T cell responses and neutralizing antibodies.
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HIV-1 基因组中经过严格选择的突变独立于 T 细胞反应和中和抗体
DOI：
10.1186/s12977-017-0371-4
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发表时间：
2017-10-10
期刊：
影响因子：
3.3
通讯作者：
Gao F
中科院分区：
文献类型：
--
作者：
Liu D;Wang C;Hora B;Zuo T;Goonetilleke N;Liu MKP;Berrong M;Ferrari G;McMichael AJ;Bhattacharya T;Perelson AS;Gao F
Mutations rapidly accumulate in the HIV-1 genome after infection. Some of those mutations are selected by host immune responses and often cause viral fitness losses. This study is to investigate whether strongly selected mutations that are not associated with immune responses result in fitness losses. Strongly selected mutations were identified by analyzing 5′-half HIV-1 genome (gag/pol) sequences from longitudinal samples of subject CH0131. The K43R mutation in the gag gene was first detected at day 91 post screening and was fixed in the viral population at day 273 while the synonymous N323tc mutation was first detected at day 177 and fixed at day 670. No conventional or cryptic T cell responses were detected against either mutation sites by ELISpot analysis. However, when fitness costs of both mutations were measured by introducing each mutation into their cognate transmitted/founder (T/F) viral genome, the K43R mutation caused a significant fitness loss while the N323tc mutation had little impact on viral fitness. The rapid fixation, the lack of detectable immune responses and the significant fitness cost of the K43R mutation suggests that it was strongly selected by host factors other than T cell responses and neutralizing antibodies.
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影响因子：
7.8
作者：
French MA;Abudulai LN;Fernandez S
通讯作者：
Fernandez S
HIV-1 GAG中的簇突变是逃避HLA-B27限制的细胞毒性T淋巴细胞反应所必需的。
影响因子：
15.3
作者：
Kelleher, A D;Long, C;Holmes, E C;Allen, R L;Wilson, J;Conlon, C;Workman, C;Shaunak, S;Olson, K;Goulder, P;Brander, C;Ogg, G;Sullivan, J S;Dyer, W;Jones, I;McMichael, A J;Rowland-Jones, S;Phillips, R E
通讯作者：
Phillips, R E
影响因子：
15.8
作者：
Hölzemer A;Thobakgale CF;Jimenez Cruz CA;Garcia-Beltran WF;Carlson JM;van Teijlingen NH;Mann JK;Jaggernath M;Kang SG;Körner C;Chung AW;Schafer JL;Evans DT;Alter G;Walker BD;Goulder PJ;Carrington M;Hartmann P;Pertel T;Zhou R;Ndung'u T;Altfeld M
通讯作者：
Altfeld M
影响因子：
15.9
作者：
Liu, Michael K. P.;Hawkins, Natalie;Goonetilleke, Nilu
通讯作者：
Goonetilleke, Nilu
影响因子：
5.4
作者：
Miura, Toshiyuki;Brockman, Mark A.;Walker, Bruce D.
通讯作者：
Walker, Bruce D.