Tables of the number of patients required in clinical trials using the logrank test.
Tables of the number of patients required in clinical trials using the logrank test.
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DOI：
10.1002/sim.4780010204
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发表时间：
1982-04-01
影响因子：
2
通讯作者：
Freedman, L S
中科院分区：
文献类型：
--
作者：
Freedman, L S
对数秩检验通常用于分析慢性疾病（如癌症）的临床试验。此类试验所需患者数量的现有表格是基于两个比例的直接比较。本文介绍了在临床试验中使用对数秩检验所需的数字表，并介绍了它们的使用。在无事件比例较小的情况下，所需的数字比现有表格中的数字小得多，但在其他情况下则相当。
The logrank test is commonly used in the analysis of clinical trials in chronic diseases such as cancer. Existing tables for the number of patients required in such trials are based on the direct comparison of two proportions. This paper presents tables of numbers required in clinical trials using the logrank test and describes their use. The numbers required are considerably smaller than those in existing tables when the event-free proportions are small, but otherwise comparable.