Emergence of Divergent Zaire Ebola Virus Strains in Democratic Republic of the Congo in 2007 and 2008
Emergence of Divergent Zaire Ebola Virus Strains in Democratic Republic of the Congo in 2007 and 2008
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DOI：
10.1093/infdis/jir364
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发表时间：
2011-11-01
影响因子：
6.4
通讯作者：
Leroy, Eric
中科院分区：
文献类型：
--
作者：
Grard, Gilda;Biek, Roman;Leroy, Eric
方法：研究方法。每一次暴发的病毒都被分离出来，并对全长基因组进行了特征分析。然后进行系统发育分析，以表征与先前描述的病毒的关系。这两种Luebo病毒几乎完全相同，但与刚果民主共和国已知的A系病毒或加蓬-刚果共和国地区遇到的B系病毒的后代没有亲缘关系，但它们有共同的祖先。我们的发现有力地表明，2007年Luebo疫情不是由以前确定的疫源地的病毒传播造成的，而是由独立的病毒出现造成的。先前确定的与已知携带扎伊尔埃博拉病毒RNA的迁徙蝙蝠物种之间的流行病学联系支持了病毒从这个广泛分布的水库溢出的假说。Luebo2007和Luebo2008病毒之间的高度相似性表明，当地野生动物种群(最有可能是蝙蝠)受到了感染，并使当地病毒得以持续并年复一年地重新出现。
Methods. Viruses of each outbreak were isolated and the full-length genomes were characterized. Phylogenetic analysis was then undertaken to characterize the relationships with previously described viruses.Results. The 2 Luebo viruses are nearly identical but are not related to lineage A viruses known in DRC or to descendants of the lineage B viruses encountered in the Gabon-Republic of the Congo area, with which they do, however, share a common ancestor.Conclusions. Our findings strongly suggest that the Luebo 2007 outbreak did not result from viral spread from previously identified foci but from an independent viral emergence. The previously identified epidemiological link with migratory bat species known to carry Zaire ebolavirus RNA support the hypothesis of viral spillover from this widely dispersed reservoir. The high level of similarity between the Luebo2007 and Luebo2008 viruses suggests that local wildlife populations (most likely bats) became infected and allowed local viral persistence and reemergence from year to year.