Brief screening tool for mild cognitive impairment in older Japanese: Validation of the Japanese version of the Montreal Cognitive Assessment
Brief screening tool for mild cognitive impairment in older Japanese: Validation of the Japanese version of the Montreal Cognitive Assessment
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DOI：
10.1111/j.1447-0594.2010.00585.x
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发表时间：
2010-07-01
影响因子：
3.3
通讯作者：
Shinkai, Shoji
中科院分区：
文献类型：
--
作者：
Fujiwara, Yoshinori;Suzuki, Hiroyuki;Shinkai, Shoji
目的：由Nasreddine博士（Nasreddine et al. 2005）开发的蒙特利尔认知评估（莫卡）是一种用于检测轻度认知障碍（MCI）老年人的简短认知筛查工具。我们研究了日本版本的莫卡（MoCA-J）在老年日本subjects.Methods的可靠性和有效性：对象被招募从东京都老年病医院的门诊记忆诊所或社区为基础的医疗健康检查，在2008年。对96名老年受试者进行MoCA-J、简易精神状态检查（MMSE）、长谷川痴呆量表（HDS-R）修订版、临床痴呆评定量表（CDR）和常规神经心理成套测验。30名受试者患有轻度阿尔茨海默病（AD），30名受试者患有轻度阿尔茨海默病（MCI），36名正常对照。结果：MoCA-J的Cronbach's alpha作为内部一致性指数为0.74。莫卡的重测信度为0.88（P <0.001），组内相关系数为0.88（P < 0.001）。MoCA-J评分与MMSE（r = 0.83，P < 0.001）、HDS-R（r = 0.79，P < 0.001）和CDR（r =-0.79，P < 0.001）评分高度相关。通过MoCA-J预测MCI和AD组的受试者-操作者曲线下面积（AUC）分别为0.95（95%置信区间[CI] = 0.90-1.00）和0.99（95% CI = 0.00-1.00）。MMSE和HDS-R的相应值分别为0.85（95%CI = 0.75-0.95）和0.97（95%CI = 0.00-1.00），以及0.86（95%CI = 0.76-0.95）和0.97（95%CI = 0.00-1.00）。结论：MoCA-J可作为MCI筛查的一种有效的认知功能测试，可推荐用于基层临床和社区老年健康筛查。Geriatr Gerontol Int 2010; 10：225-232.
Aim:The Montreal Cognitive Assessment (MoCA), developed by Dr Nasreddine (Nasreddine et al. 2005), is a brief cognitive screening tool for detecting older people with mild cognitive impairment (MCI). We examined the reliability and validity of the Japanese version of the MoCA (MoCA-J) in older Japanese subjects.Methods:Subjects were recruited from the outpatient memory clinic of Tokyo Metropolitan Geriatric Hospital or community-based medical health check-ups in 2008. The MoCA-J, the Mini-Mental State Examination (MMSE), the revised version of Hasegawa's Dementia Scale (HDS-R), Clinical Dementia Rating (CDR) scale, and routine neuropsychological batteries were conducted on 96 older subjects. Mild Alzheimer's disease (AD) was found in 30 subjects and MCI in 30, with 36 normal controls.Results:The Cronbach's alpha of MoCA-J as an index of internal consistency was 0.74. The test-retest reliability of MoCA, using intraclass correlation coefficient between the scores at baseline survey and follow-up survey 8 weeks later was 0.88 (P < 0.001). MoCA-J score was highly correlated with MMSE (r = 0.83, P < 0.001), HDS-R (r = 0.79, P < 0.001) and CDR (r = -0.79, P < 0.001) scores. The areas under receiver-operator curves (AUC) for predicting MCI and AD groups by the MoCA-J were 0.95 (95% confidence interval [CI] = 0.90-1.00) and 0.99 (95% CI = 0.00-1.00), respectively. The corresponding values for MMSE and HDS-R were 0.85 (95% CI = 0.75-0.95) and 0.97 (95% CI = 0.00-1.00), and 0.86 (95% CI = 0.76-0.95) and 0.97 (95% CI = 0.00-1.00), respectively. Using a cut-off point of 25/26, the MoCA-J demonstrated a sensitivity of 93.0% and a specificity of 87.0% in screening MCI.Conclusion:The MoCA-J could be a useful cognitive test for screening MCI, and could be recommended in a primary clinical setting and for geriatric health screening in the community. Geriatr Gerontol Int 2010; 10: 225-232.