INCOMPLETE SULFOMUCIN-SECRETING INTESTINAL METAPLASIA FOR GASTRIC-CANCER - PRELIMINARY DATA FROM A PROSPECTIVE-STUDY FROM 3 CENTERS

INCOMPLETE SULFOMUCIN-SECRETING INTESTINAL METAPLASIA FOR GASTRIC-CANCER - PRELIMINARY DATA FROM A PROSPECTIVE-STUDY FROM 3 CENTERS
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DOI：
10.1136/gut.26.12.1319
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发表时间：
1985-01-01
期刊：
GUT
影响因子：
24.5
通讯作者：
ZEEGEN, R
ZEEGEN, R
中科院分区：
医学1区
文献类型：
--
作者：
FILIPE, MI;POTET, F;ZEEGEN, R

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对胃活检进行了一项联合前瞻性长期研究，以调查I型、II型和III型肠上皮化生的发生率、分布和在选择高危癌症患者中的价值。这项研究是基于三个中心之间达成协议的内窥镜检查，组织学解释，粘蛋白组织化学。本文报告了1981-1982年对1350例胃活检的结果。在267例活检中发现肠上皮化生（20%），常见于癌（71%），在良性疾病如胃溃疡（39%）和慢性胃炎（24%）中较少见，但在“正常”（3%）中罕见。I型肠上皮化生在所有肠上皮化生活检中占主导地位（73%），在良性疾病中最常见，胃溃疡中占70%，慢性胃炎中占76%。III型肠上皮化生（不完全分泌型肠上皮化生）仅占所有肠上皮化生活检的9.8%，并且在癌中的发生率（35%）高于良性疾病（7%）（p < 0.001）。这些结果表明，肠上皮化生类型可能有不同的恶性潜力，他们的识别可能是有用的，在筛选患者早期发现癌症。
A joint prospective long term study of gastric biopsies has been undertaken to survey intestinal metaplasia Types I, II, and III in terms of their incidence, distribution and value in the selection of high risk cancer patients. This study is based on protocols agreed between three centres for endoscopy, histological interpretation, and mucin histochemistry. The results on the first 1350 gastric biopsies examined during 1981-1982 are presented. Intestinal metaplasia was found in 267 biopsies (20%), being common in association with carcinoma (71%), less so in benign conditions such as gastric ulcer (39%), and chronic gastritis (24%), but rare in ''normal'' (3%). Type I intestinal metaplasia was predominant (73%) in all the biopsies with intestinal metaplasia and was most common in benign conditions, 70% in gastric ulcer and 76% in chronic gastritis. Type III intestinal metaplasia (incomplete sulphomucin-secreting intestinal metaplasia) was recorded in only 9.8% of all the biopsies with intestinal metaplasia and had a higher incidence in carcinoma (35%), than in benign conditions (7%) (p < 0.001). These results suggest that intestinal metaplasia types may have different malignant potential and their identification may be useful in screening patients for early detection of cancer.