Effect of estradiol on pregnant mare's serum (PMS)-induced ovulation in the immature rat.
Effect of estradiol on pregnant mare's serum (PMS)-induced ovulation in the immature rat.
复制标题
雌二醇对孕马血清（PMS）诱导的未成熟大鼠排卵的影响。
DOI：
10.1016/s0015-0282(16)39260-3
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发表时间：
1972
影响因子：
6.7
通讯作者：
M. Zarrow
中科院分区：
文献类型：
--
作者：
K. R. Park;M. Zarrow
在PMS同时给予雌二醇似乎抑制PMS诱导的24日龄大鼠在治疗后72小时处死的排卵。然而，48小时尸检显示发生了过早排卵。经前综合征后24-52 h注射雌激素，未发生排卵提前。2.5-80 μ g剂量的雌二醇可诱发排卵提前，而<2.5 μ g剂量的雌二醇则无效。雌激素与孕激素在诱导过早排卵中相互作用。然而，孕酮对LH释放的作用依赖于先前暴露于足够水平的雌激素。雌二醇对卵巢对促排卵剂量80 μ g LH的敏感性没有影响。经前综合征时同时注射雌二醇引起的排卵反应在27-32 h内可被戊巴比妥阻断，但在24或33 h内不能被阻断。这些结果表明，在PMS的同时注射雌二醇通过影响控制LH释放的CNS机制来促进PMS诱导的排卵。
Oestradiol administered at the same time as PMS appeared to inhibit PMS-induced ovulation in 24-day-old rats killed 72 h after treatment. However, autopsy at 48 h showed that a premature ovulation had occurred. Premature ovulation did not occur when the oestrogen was injected 24-52 h after PMS. A dose of 2.5-80 mu g oestradiol induced premature ovulation, but one of <2.5 mu g had no effect. Oestradiol interacted with progesterone in the induction of premature ovulation. However, the action of progesterone on LH release was dependent on a preceding exposure to an adequate level of oestrogen. Oestradiol had no effect on ovarian sensitivity to an ovulatory dose of 80 mu g of LH. The premature ovulatory response induced by the injection of oestradiol at the same time as PMS was blocked by pentobarbital from 27-32 h, but not at 24 or 33 h. These results suggest that the injection of oestradiol at the same time as PMS advances PMS-induced ovulation by means of an effect upon the CNS mechanism controlling the release of LH.