Effects of methylphenidate in children with attention deficit hyperactivity disorder: a near-infrared spectroscopy study with CANTAB®.
Effects of methylphenidate in children with attention deficit hyperactivity disorder: a near-infrared spectroscopy study with CANTAB®.
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DOI：
10.1186/s13034-014-0032-5
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发表时间：
2014
影响因子：
5.6
通讯作者：
Kosaka H
中科院分区：
文献类型：
--
作者：
Matsuura N;Ishitobi M;Arai S;Kawamura K;Asano M;Inohara K;Fujioka T;Narimoto T;Wada Y;Hiratani M;Kosaka H
广泛的证据支持哌醋甲酯(MPH)诱导的前额叶皮质(PFC)功能的增强和注意缺陷多动障碍(ADHD)患者行为症状的改善。虽然ADHD患者的工作记忆(WM)被假设为受损，但还没有药理学研究用近红外光谱(NIRS)来检验视觉空间WM(VSWM)。本研究旨在探讨在VSWM任务中，MPH对ADHD儿童神经心理表现和血流动力学激活的急性影响。受试组包括10名男孩和1名女孩，他们之前被诊断为ADHD。进行了两项难度不同的VSWM任务。这是第一项关于MPH对ADHD儿童的药理作用的研究，以评估同时使用NIRS的PFC的血流动力学反应。在空间工作记忆(SWM)和空间广度(SSP)任务的得分上，MPH-OFF和MPH-ON条件下的得分没有显著差异。然而，只有在SWM任务中才发现对PFC中氧合血红蛋白水平变化的显著mph效应。这些发现表明，PFC的激活可能会受到mph的影响，这取决于特定任务的困难程度。尽管mph引起的行为变化可能很明显，也可能不明显，但即使在认知任务中没有观察到表现变化，近红外光谱测量也可能有助于评估mph的心理影响。
A wide range of evidence supports the methylphenidate (MPH)-induced enhancement of prefrontal cortex (PFC) functioning and improvements in behavioral symptoms in patients with attention deficit hyperactivity disorder (ADHD). Although working memory (WM) has been hypothesized to be impaired in patients with ADHD, no pharmacological studies have examined visuospatial WM (VSWM) with near-infrared spectroscopy (NIRS). The present study was designed to investigate the acute effects of MPH on neuropsychological performance and hemodynamic activation in children with ADHD during VSWM tasks. The subject group included 10 boys and 1 girl previously diagnosed with ADHD. Two VSWM tasks of differing degrees of difficulty were conducted. This is the first study on the pharmacological effects of MPH in children with ADHD to evaluate hemodynamic responses in the PFC with simultaneous NIRS. No significant differences were found in the scores for both spatial working memory (SWM) and score of spatial span (SSP) tasks between the MPH-off and MPH–on conditions. However, a significant MPH-effect on changes in oxy-hemoglobin levels in the PFC was found only in the SWM task. These findings suggest that PFC activation might be affected by MPH, depending on the degree of difficulty of the particular task. Although the MPH-induced change on behavior may or may not be obvious, NIRS measurements might be useful for assessing the psychological effects of MPH even when performance changes were not observed in the cognitive tasks.