The direction of shift-work rotation impacts metabolic risk independent of chronotype and social jetlag - An exploratory pilot study
The direction of shift-work rotation impacts metabolic risk independent of chronotype and social jetlag - An exploratory pilot study
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DOI：
10.3109/07420528.2014.957295
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发表时间：
2014-12-01
影响因子：
2.8
通讯作者：
Skene, Debra J.
中科院分区：
文献类型：
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作者：
Kantermann, Thomas;Duboutay, Francoise;Skene, Debra J.
这项初步研究的目的是探索在不同轮班工作中受雇的钢铁工人代谢异常的风险。一家钢铁厂的男性工人[16人受雇于快速顺时针旋转(CW)，18人受雇于慢速逆时针旋转(CC)，9天工人(DW)；平均年龄43.3+/-SD 6.8岁]，在他们目前的工作时间表中至少有5年经验。空腹采血测定血糖、胰岛素、载脂蛋白A、载脂蛋白B、高密度脂蛋白、低密度脂蛋白、总胆固醇、甘油三酯、低密度脂蛋白、C反应蛋白、白介素8、25(OH)D。计算HOMA指数(稳态模型评估)以评估胰岛素抵抗、β细胞功能和糖尿病风险。通过问卷调查收集了有关人口统计学、健康状况、兴奋剂、睡眠、社交和工作生活、时型(夹带阶段)和社会时差(工作日睡眠中期与自由天数的差异)作为昼夜节律紊乱替代指标的信息。时型和社会时差与任何代谢风险血液标记物都没有关联。3组间25(OH)D、ApoA、ApoB、C反应蛋白、高密度脂蛋白、IL-8、胰岛素、低密度脂蛋白/载脂蛋白B比值、总胆固醇、甘油三酯水平差异无统计学意义。虽然我们确实观察到了其中一些标记的绝对差异，但我们研究人群的小样本量可能会阻止这些差异具有统计学意义。CW组的空腹血糖和HOMA指数显著低于DW组和CC组，表明代谢风险较低。CW工人空腹血糖和HOMA指数较低的原因尚不清楚。未来有必要对不同轮班的工人进行研究，以更好地了解轮班工作对个体工人及其健康指数的不同影响。
The aim of this pilot study was to explore the risk of metabolic abnormalities in steel workers employed in different shift-work rotations. Male workers in a steel factory [ 16 employed in a fast clockwise rotation (CW), 18 in slow counterclockwise rotation (CC), 9 day workers (DW); mean age 43.3 +/- SD 6.8 years] with at least 5 years experience in their current work schedule participated. All workers provided fasting blood samples between 06: 00 and 08: 00 h for plasma glucose, insulin, apo-lipoproteins A and B (ApoA, ApoB), high-and low-density lipoproteins (HDL and LDL), total cholesterol (tCH), triglycerides (TG), minimally oxidized (mox) LDL, C-reactive protein (CRP), interleukin-8 (IL-8) and serum 25-hydroxyvitamin D (25(OH) D). HOMA index (homeostatic model assessment) was calculated to evaluate insulin resistance, beta cell function and risk of diabetes. Information on demographics, health, stimulants, sleep, social and work life, chronotype (phase of entrainment) and social jetlag (difference between mid-sleep on workdays and free days) as a surrogate for circadian disruption was collected by questionnaire. Neither chronotype nor social jetlag was associated with any of the metabolic risk blood markers. There were no significant differences in 25(OH) D, ApoA, ApoB, CRP, HDL, IL-8, insulin, LDL, mox-LDL, mox-LDL/ApoB ratio, tCH and TG levels between the three work groups. Although we did observe absolute differences in some of these markers, the small sample size of our study population might prevent these differences being statistically significant. Fasting glucose and HOMA index were significantly lower in CW compared to DW and CC, indicating lower metabolic risk. Reasons for the lower fasting glucose and HOMA index in CW workers remains to be clarified. Future studies of workers in different shift rotations are warranted to understand better the differential effects of shift-work on individual workers and their health indices.