Do corticosteroids prevent post‐herpetic neuralgia?
Do corticosteroids prevent post‐herpetic neuralgia?
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皮质类固醇可以预防带状疱疹后神经痛吗？
DOI：
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发表时间：
1980
影响因子：
10.3
通讯作者：
A. Basheer
中科院分区：
文献类型：
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作者：
K. Keczkes;A. Basheer
40名年龄在50岁以上、患有早期、重度带状疱疹疼痛的健康患者被随机分为两组进行治疗。20名患者每日服用强的松龙40毫克，并在4周内逐步减量，而另外20名患者每天服用卡马西平100毫克，每天4次。卡马西平治疗组的20名患者中有13名(65%)出现持续2年的带状疱疹后神经痛，而接受强的松龙治疗的20名患者中只有3名(15%)仅出现持续6个月的带状疱疹后神经痛。因此，在强的松龙治疗组中，带状疱疹后神经痛的发生率和持续时间显著减少。两组均未发生播散性带状疱疹或其他并发症。
Forty otherwise healthy patients over 50 years of age with early, severe painful herpes zoster were randomly allocated to two groups for treatment. Twenty patients received prednisolone 40 mg daily with gradual reduction over a period of 4 weeks, whilst the other twenty patients received carbamazepine 100 mg four times daily. Thirteen of the twenty patients (65%) in the carbamazepine treated group developed post‐herpetic neuralgia lasting up to 2 years, whilst only three of the twenty prednisolone treated patients (15%) had post‐herpetic neuralgia lasting up to 6 months only. Thus the incidence and duration of post‐herpetic neuralgia were considerably reduced in the prednisolone treated group. In neither group did disseminated zoster or other complications occur.