Nonspecific vasodilatation during transdermal iontophoresis -: the effect of voltage over the skin
Nonspecific vasodilatation during transdermal iontophoresis -: the effect of voltage over the skin
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DOI：
10.1016/s0026-2862(03)00002-5
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发表时间：
2003-05-01
影响因子：
3.1
通讯作者：
Sjöberg, F
中科院分区：
文献类型：
--
作者：
Droog, EJ;Sjöberg, F
我们使用激光多普勒灌注成像（LDPI）研究离子导入过程中的非特异性血管舒张。在离子电渗疗法研究中，非特异性血管舒张是由于皮肤上的电流或施加的电压而发生的。我们进行了剂量-反应测量，以研究在氯化钠和去离子水的离子电渗过程中载体的离子强度对非特异性血管舒张的影响，同时我们监测皮肤上的电压。我们发现，阳极和阴极离子电渗诱导的电压在皮肤上，这是依赖于测试溶液的离子强度。非特异性血管舒张在阳极离子电渗不太明显，比在阴极离子电渗，是独立的电压在皮肤上。阴极离子导入的非特异性血管舒张作用与皮肤电压有关，可能是通过局部感觉神经的去极化介导的。因此，在使用阴极离子电渗疗法的实验中，当检查血管活性药物时，载体和药物的离子强度是重要的，因为需要控制非特异性血管舒张。由于我们观察到的血管舒张在离子电渗区域内分布不均匀，因此LDPI可以提供比传统激光多普勒灌注监测更准确的测量。(C)2003 Elsevier Science（美国）。All rights reserved.
We used laser Doppler perfusion imaging (LDPI) to study nonspecific vasodilatation during iontophoresis. In iontophoresis studies, nonspecific vasodilatation occurs as a result either of galvanic currents or of the applied voltage over the skin. We made dose-response measurements to study the effect of ionic strength of the vehicle on the nonspecific vasodilatation during iontophoresis of sodium chloride and deionized water, while we monitored the voltage over the skin. We found that anodal and cathodal ionotophoresis induced a voltage over the skin that was dependent on the ionic strength of the test solution. The nonspecific vasodilatation during anodal iontophoresis was less pronounced than during cathodal iontophoresis, and was independent of the voltage over the skin. The nonspecific vasodilatation in cathodal iontophoresis was related to the voltage over the skin, and was possibly mediated by depolarization of local sensory nerves. In experiments using cathodal iontophoresis, therefore, the ionic strengths of the vehicle and the drug are important when vasoactive drugs are examined, as the nonspecific vasodilatation needs to be controlled for. As the vasodilatation that we observed was heterogeneously distributed within the area of iontophoresis, LDPI may provide more accurate measurements than conventional laser Doppler perfusion monitoring. (C) 2003 Elsevier Science (USA). All rights reserved.