Fluorescent probes for live cell imaging of endogenous guanine nitration
Fluorescent probes for live cell imaging of endogenous guanine nitration
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用于内源鸟嘌呤硝化活细胞成像的荧光探针
DOI：
10.1002/cbic.201300129
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Akaike T and Arimoto H.
中科院分区：
文献类型：
--
作者：
Saito Y;Ito C;Fujii S;Sawa T;Akaike T and Arimoto H.
眼见为实：s -胍基化是调控氧化应激下信号转导的一种新的关键机制。描述了一种与蛋白质半胱氨酸（s -胍基化）反应后荧光强度增加的化学探针。该探针的使用表明s -胍基化产物定位于溶酶体中。
Seeing is believing: S-guanylation is a novel key mechanism by which signal transduction under oxidative stress is regulated. A chemical probe whose fluorescent intensity increases after the reaction with proteinous cysteine (S-guanylation) is described. The use of this probe revealed that S-guanylation products localized in lysosomes.