Syndecans as cell surface receptors: Unique structure equates with functional diversity
Syndecans as cell surface receptors: Unique structure equates with functional diversity
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DOI：
10.1016/j.matbio.2010.10.006
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发表时间：
2011-03-01
期刊：
影响因子：
6.9
通讯作者：
Oh, Eok-Soo
中科院分区：
文献类型：
--
作者：
Choi, Youngsil;Chung, Heesung;Oh, Eok-Soo
在过去的十年中，已经提出了越来越多的多配体蛋白聚糖细胞表面硫酸乙酰肝素蛋白聚糖的功能。此外，已经发现异常的多配体蛋白聚糖调节在多种病理学中起关键作用，包括癌症以及伤口愈合和炎症。作为受体，它们与细胞表面的其他分子有许多共同之处。多配体蛋白聚糖是I型跨膜分子，具有连接到肌动蛋白细胞骨架的胞质结构域，并且可以与许多调节剂相互作用。然而，由于它们的外部糖胺聚糖链，特别是硫酸乙酰肝素，它们也是高度复杂的。这种异分散性多糖具有与来自不同蛋白质家族的许多配体相互作用的潜力。在这里，我们将syndecans的结构特征与它们的一些已知功能联系起来。(C)2010 Elsevier B.V.保留所有权利。
An increasing number of functions for syndecan cell surface heparan sulfate proteoglycans have been proposed over the last decade. Moreover, aberrant syndecan regulation has been found to play a critical role in multiple pathologies, including cancers, as well as wound healing and inflammation. As receptors, they have much in common with other molecules on the cell surface. Syndecans are type I transmembrane molecules with cytoplasmic domains that link to the actin cytoskeleton and can interact with a number of regulators. However, they are also highly complex by virtue of their external glycosaminoglycan chains, especially heparan sulfate. This heterodisperse polysaccharide has the potential to interact with many ligands from diverse protein families. Here, we relate the structural features of syndecans to some of their known functions. (C) 2010 Elsevier B.V. All rights reserved.