Digoxin disposition kinetics in dogs before and during azotemia.
Digoxin disposition kinetics in dogs before and during azotemia.
复制标题
氮质血症之前和期间狗的地高辛处置动力学。
DOI：
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发表时间：
1978
影响因子：
3.5
通讯作者：
F. Marcus
中科院分区：
文献类型：
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作者：
K. Gierke;D. Perrier;M. Mayersohn;F. Marcus
本研究的目的是评价在氮质血症之前和期间对相同犬单次静脉给药后地高辛的处置动力学。使用非线性回归分析将地高辛血药浓度-时间数据拟合至多房室模型。在氮质血症期间，7只犬中有6只的地高辛生物半衰期延长，而地高辛肾清除率、体清除率和表观分布容积显著降低。地高辛“中央”室的表观体积相应增加。在这些动物中，约45%的地高辛剂量经肾脏排泄，表明犬中地高辛消除的主要非肾脏成分。这种非肾脏消除在氮质血症期间没有改变，尽管肾脏清除率降低了61%。
The purpose of this study was to evaluate the disposition kinetics of digoxin after the administration of a single intravenous dose to the same dogs before and during azotemia. The digoxin plasma concentration-time data were fitted to a multicompartment model using nonlinear regression analysis. During azotemia, the biological half-life of digoxin was prolonged in six of seven dogs, while digoxin renal clearance, body clearance and apparent volume of distribution were significantly decreased. There was a corresponding increase in the apparent volume of the "central" compartment of digoxin. Approximately 45% of a digoxin dose was excreted by the kidney in these animals indicating a substantial nonrenal component to digoxin elimination in the dog. This nonrenal elimination did not change during azotemia, despite a decrease in renal clearance by 61%.