Neural correlates of tactile prepulse inhibition: a functional MRI study in normal and schizophrenic subjects
Neural correlates of tactile prepulse inhibition: a functional MRI study in normal and schizophrenic subjects
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DOI：
10.1016/s0925-4927(02)00123-3
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发表时间：
2003-02-15
影响因子：
2.3
通讯作者：
Sharma, T
中科院分区：
文献类型：
--
作者：
Kumari, V;Gray, JA;Sharma, T
惊吓反射的预脉冲抑制（PPI）是指一种弱的前刺激，即预脉冲，对紧跟着的强感觉刺激，即脉冲的抑制反应的能力。发现PPI在许多精神和神经疾病中缺乏，这些疾病与边缘和皮质-白纹状体-丘脑回路在某种程度上的异常有关。我们应用全脑功能磁共振成像来阐明PPI的神经相关性，在(i)健康受试者和（ii）精神分裂症患者组中使用气雾刺激作为预脉冲和脉冲。与单独脉冲刺激时的大脑激活相比，120秒的脉冲前加脉冲刺激时的大脑激活。在健康受试者中，PPI与双侧延伸至海马和丘脑的纹状体、右侧额下回和双侧下顶叶/边缘上回的激活增加有关，与右侧小脑和左侧内侧枕叶的激活减少有关。与精神分裂症患者相比，健康受试者的所有激活区域都表现出更大的反应，精神分裂症患者也表现出更低的PPI趋势。研究结果表明，PPI涉及纹状体、海马、丘脑、额叶和顶叶皮质区。这些区域的任何功能障碍都可能是精神分裂症患者PPI降低的基础。(C) 2002爱思唯尔科学爱尔兰有限公司版权所有。
Prepulse inhibition (PPI) of the startle reflex refers to the ability of a weak prestimulus, the prepulse, to inhibit the response to a closely following strong sensory stimulus, the pulse. PPI is found to be deficient in a number of psychiatric and neurological disorders associated with abnormalities at some level in the limbic and cortico-pallidostriato-thalamic circuitry. We applied whole-brain functional magnetic resonance imaging to elucidate the neural correlates of PPI using airpuff stimuli as both the prepulse and the pulse in groups of (i) healthy subjects and (ii) schizophrenic patients. Cerebral activation during prepulse-plus-pulse stimuli with stimulus-onset asynchronies of 120 ins was contrasted with activation during pulse-alone stimuli. In healthy subjects, PPI was associated with increased activation bilaterally in the striatum extending to hippocampus and thalamus, right inferior frontal gyrus and bilateral inferior parietal lobe/supramarginal gyrus, and with decreased activation in the right cerebellum and left medial occipital lobe. All activated regions showed significantly greater response in healthy subjects than schizophrenic patients, who also showed a trend for lower PPI. The findings demonstrate involvement of the striatum, hippocampus, thalamus, and frontal and parietal cortical regions in PPI. Dysfunctions in any of these regions may underlie observations of reduced PPI in schizophrenia. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.