The functions and applications of extracellular vesicles derived from Mycobacterium tuberculosis
The functions and applications of extracellular vesicles derived from Mycobacterium tuberculosis
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DOI：
10.1016/j.biopha.2023.115767
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发表时间：
2023-10-20
影响因子：
7.5
通讯作者：
Zhu，Hong
中科院分区：
文献类型：
--
作者：
Li，Yujie;Qian，Yingfen;Zhu，Hong
来源于细菌的胞外囊泡在细菌生物生理学和宿主-病原体相互作用中起着重要作用。结核病）在体外和体内产生EV，其中膜结合的纳米颗粒促进生物分子（包括脂质、蛋白质、核酸和糖脂）的传输，同时与宿主远程相互作用。虽然EV在分枝杆菌感染中的研究仍处于起步阶段，但它已经揭示了M的一个全新方面。结核病与宿主的相互作用可能对结核病（TB）的发病机制产生影响。在本文中，我们讨论了M的重要功能。本文介绍了结核病EV在阐明囊泡生物发生和调节细胞免疫反应的机制方面的最新进展，以及在开发新的结核病预防和治疗或诊断策略方面的最新进展和挑战。
Extracellular vesicles (EVs) originating from bacteria function critical roles in bacterial biologic physiology and host-pathogen interactions.Mycobacterium tuberculosis(M. tuberculosis) produces EVs both in vitro and in vivo, with membrane-bound nanoparticles facilitating the transmission of biological molecules including lipids, proteins, nucleic acids and glycolipids, while interacting remotely with the host. Although studies of EVs in mycobacterial infections is still in its infancy, it has already revealed an entirely new aspect ofM. tuberculosis-host interactions that may have implications for tuberculosis (TB) pathogenesis. In this review, we discuss the significant functions ofM. tuberculosisEVs in elucidating the mechanisms underlying vesicle biogenesis and modulating cellular immune responses, as well as the recent advances and challenges in the development of novel preventive and therapeutic or diagnostic strategies against TB.
影响因子：
1.1
作者：
Yan Z;Wang H;Mu L;Hu ZD;Zheng WQ
通讯作者：
Zheng WQ
影响因子：
4.3
作者：
Drage, Michael G.;Pecora, Nicole D.;Hise, Amy G.;Febbraio, Maria;Silverstein, Roy L.;Golenbock, Douglas T.;Boom, W. Henry;Harding, Clifford V.
通讯作者：
Harding, Clifford V.