Glioneuronal tumor with neuropil-like islands
Glioneuronal tumor with neuropil-like islands
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DOI：
10.1053/hupa.2000.19433
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发表时间：
2000-11-01
期刊：
影响因子：
3.3
通讯作者：
Abramovich, CM
中科院分区：
文献类型：
--
作者：
Prayson, RA;Abramovich, CM
混合性胶质神经元肿瘤在中枢神经系统是相对少见的肿瘤。最近，一个不寻常的胶质神经元肿瘤发生在成人标记的组织学上的神经纤维样岛被描述。我们提出一个类似的情况下出现在一个23岁的妇女谁提出头痛和癫痫发作和影像学研究被指出有额颞叶肿块。病人接受了部分切除肿瘤，这在组织学上类似于间变性星形细胞瘤，并接受了一个疗程的放疗和化疗。癫痫发作频率的增加和神经影像学上肿瘤体积的扩大促使再次切除肿瘤。第二次切除的特点是类似灰质的组织岛，白色物质中有轻微非典型的神经元和神经胶质细胞。这些岛与突触素染色阳性，而不与胶质细胞酸性蛋白染色。轻度血管增生和中度核多形性也是肿瘤的特征。未观察到坏死区域，MIB-1标记指数为18.1%。在大约40%的肿瘤细胞核中观察到P53免疫反应性，这种病变被认为是一种临床上具有侵袭性的胶质神经元肿瘤，具有不寻常的和独特的组织学表型。《人文哲学》31：1435-1438。Copyright（C）2000 by W.B.桑德斯公司
Mixed glioneuronal neoplasms are relatively uncommon tumors in the central nervous system. Recently, an unusual glioneuronal tumor arising in adults marked histologically by neuropil-like islands was described. We present a similar case arising in a 23-year-old woman who presented with headaches and seizures and on imaging studies was noted to have a frontal-temporal lobe mass. The patient underwent partial resection of the tumor, which histologically resembled anaplastic astrocytoma, and received a course of radiation therapy and chemotherapy. increasing seizure frequency and expanding size on neuroimaging prompted a re-excision of the tumor. The second resection was marked by islands of tissue resembling gray matter with slightly atypical neuronal and glial cells situated in the white matter. These islands stained positively with synaptophysin and did not stain with glial fibrillary acid protein. Mild vascular proliferation and moderate nuclear pleomorphism also characterized the tumor. Areas of necrosis were not noted, A MIB-1 labeling index of 18.1% was noted. P53 immunoreactivity was observed in approximately 40% of tumor cell nuclei, This lesion is felt to represent a clinically aggressive glioneuronal neoplasm with an unusual and distinctive histologic phenotype. HUM PATHOL 31:1435-1438. Copyright (C) 2000 by W.B. Saunders Company.