Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice
Contribution of individual olfactory receptors to odor-induced attractive or aversive behavior in mice
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DOI：
10.1038/s41467-018-07940-1
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发表时间：
2019-01-14
影响因子：
16.6
通讯作者：
Touhara, Kazushige
中科院分区：
文献类型：
--
作者：
Horio, Nao;Murata, Ken;Touhara, Kazushige
气味物质被多种嗅觉受体识别，并通过嗅觉系统诱导小鼠产生吸引或厌恶等先天性行为。然而，个体OR的作用尚不清楚。麝香酮被包括MOR 215 -1和MOR 214 -3在内的一些OR识别，并吸引雄性小鼠。使用M0 R 215 -1敲除小鼠的气味偏好测试揭示了M0 R 215 -1和其他OR（可能包括M0 R 214 -3）参与吸引。（Z）-5-十四烯-1-醇（Z5-14：OH）激活类似于3个OR，包括Olfr 288，并且在低水平下引起吸引，但在高水平下引起厌恶。Olfr 288基因敲除小鼠没有表现出吸引力，但表现出厌恶，这表明Olfr 288参与了对Z5-14：OH的偏好，而其他低亲和力Z5-14：OH受体的激活引起厌恶。每个OR似乎都向具有不同效价的神经回路发送信号，导致某种行为。多个OR刺激的最终输出行为由激活的OR编码的化合价的总和（相加或竞争）决定。
Odorants are recognized by multiple olfactory receptors (ORs) and induce innate behaviors like attraction or aversion via olfactory system in mice. However, a role of an individual OR is unclear. Muscone is recognized by a few ORs including MOR215-1 and MOR214-3, and attracts male mice. Odor preference tests using MOR215-1 knockout mice revealed that MOR215-1 and other OR(s), possibly including MOR214-3, are involved in the attraction. (Z)-5-tetradecen-1-ol (Z5-14:OH) activates similar to 3 ORs, including Olfr288, and evokes attraction at low levels but aversion at higher levels. Olfr288 knockout mice show no attraction but aversion, suggesting Olfr288 is involved in preference for Z5-14:OH, whereas activation of other low-affinity Z5-14:OH receptors evokes aversion. Each OR appears to send a signal to a neural circuit that possesses distinct valence, leading to a certain behavior. The final output behavior with multiple ORs stimulation is determined by summation (addition or competition) of valences coded by activated ORs.